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Uncovering the Genetic History of the Present-Day Greenlandic Population
Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289681/ https://www.ncbi.nlm.nih.gov/pubmed/25557782 http://dx.doi.org/10.1016/j.ajhg.2014.11.012 |
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author | Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn S. Crawford, Jacob E. Bjerregaard, Peter Jørgensen, Marit E. Grarup, Niels Gulløv, Hans Christian Linneberg, Allan Pedersen, Oluf Hansen, Torben Nielsen, Rasmus Albrechtsen, Anders |
author_facet | Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn S. Crawford, Jacob E. Bjerregaard, Peter Jørgensen, Marit E. Grarup, Niels Gulløv, Hans Christian Linneberg, Allan Pedersen, Oluf Hansen, Torben Nielsen, Rasmus Albrechtsen, Anders |
author_sort | Moltke, Ida |
collection | PubMed |
description | Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200,000 SNPs from more than 10% of the adult Greenlandic population (n = 4,674). We found that recent gene flow from Europe has had a substantial impact on the population: more than 80% of the Greenlanders have some European ancestry (on average ∼25% of their genome). However, we also found that the amount of recent European gene flow varies across Greenland and is far smaller in the more historically isolated areas in the north and east and in the small villages in the south. Furthermore, we found that there is substantial population structure in the Inuit genetic component of the Greenlanders and that individuals from the east, west, and north can be distinguished from each other. Moreover, the genetic differences in the Inuit ancestry are consistent with a single colonization wave of the island from north to west to south to east. Although it has been speculated that there has been historical admixture between the Norse Vikings who lived in Greenland for a limited period ∼600–1,000 years ago and the Inuit, we found no evidence supporting this hypothesis. Similarly, we found no evidence supporting a previously hypothesized admixture event between the Inuit in East Greenland and the Dorset people, who lived in Greenland before the Inuit. |
format | Online Article Text |
id | pubmed-4289681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-42896812015-07-08 Uncovering the Genetic History of the Present-Day Greenlandic Population Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn S. Crawford, Jacob E. Bjerregaard, Peter Jørgensen, Marit E. Grarup, Niels Gulløv, Hans Christian Linneberg, Allan Pedersen, Oluf Hansen, Torben Nielsen, Rasmus Albrechtsen, Anders Am J Hum Genet Article Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200,000 SNPs from more than 10% of the adult Greenlandic population (n = 4,674). We found that recent gene flow from Europe has had a substantial impact on the population: more than 80% of the Greenlanders have some European ancestry (on average ∼25% of their genome). However, we also found that the amount of recent European gene flow varies across Greenland and is far smaller in the more historically isolated areas in the north and east and in the small villages in the south. Furthermore, we found that there is substantial population structure in the Inuit genetic component of the Greenlanders and that individuals from the east, west, and north can be distinguished from each other. Moreover, the genetic differences in the Inuit ancestry are consistent with a single colonization wave of the island from north to west to south to east. Although it has been speculated that there has been historical admixture between the Norse Vikings who lived in Greenland for a limited period ∼600–1,000 years ago and the Inuit, we found no evidence supporting this hypothesis. Similarly, we found no evidence supporting a previously hypothesized admixture event between the Inuit in East Greenland and the Dorset people, who lived in Greenland before the Inuit. Elsevier 2015-01-08 2014-12-31 /pmc/articles/PMC4289681/ /pubmed/25557782 http://dx.doi.org/10.1016/j.ajhg.2014.11.012 Text en ©2015 by The American Society of Human Genetics. All rights reserved. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn S. Crawford, Jacob E. Bjerregaard, Peter Jørgensen, Marit E. Grarup, Niels Gulløv, Hans Christian Linneberg, Allan Pedersen, Oluf Hansen, Torben Nielsen, Rasmus Albrechtsen, Anders Uncovering the Genetic History of the Present-Day Greenlandic Population |
title | Uncovering the Genetic History of the Present-Day Greenlandic Population |
title_full | Uncovering the Genetic History of the Present-Day Greenlandic Population |
title_fullStr | Uncovering the Genetic History of the Present-Day Greenlandic Population |
title_full_unstemmed | Uncovering the Genetic History of the Present-Day Greenlandic Population |
title_short | Uncovering the Genetic History of the Present-Day Greenlandic Population |
title_sort | uncovering the genetic history of the present-day greenlandic population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289681/ https://www.ncbi.nlm.nih.gov/pubmed/25557782 http://dx.doi.org/10.1016/j.ajhg.2014.11.012 |
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