Comparison between Single Dose Azithromycin and Six Doses, 3 Day Norfloxacin for Treatment of Cholera in Adult

AIM: To evaluate the efficacy of single dose Azithromycin (1 gram) in treatment of cholera in adults. A randomized, controlled clinical trial on 120 adults with acute watery diarrhoea and moderate to severe dehydration compared the efficacy of azithromycin (1 gram) single dose and Norfloxacin (400 m...

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Autores principales: Bhattacharya, M. K., Kanungo, S, Ramamurthy, T, Rajendran, K, Sinha, A, Bhattacharya, A, Sarkar, B. Sharma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289698/
https://www.ncbi.nlm.nih.gov/pubmed/25598755
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author Bhattacharya, M. K.
Kanungo, S
Ramamurthy, T
Rajendran, K
Sinha, A
Bhattacharya, A
Sarkar, B. Sharma
author_facet Bhattacharya, M. K.
Kanungo, S
Ramamurthy, T
Rajendran, K
Sinha, A
Bhattacharya, A
Sarkar, B. Sharma
author_sort Bhattacharya, M. K.
collection PubMed
description AIM: To evaluate the efficacy of single dose Azithromycin (1 gram) in treatment of cholera in adults. A randomized, controlled clinical trial on 120 adults with acute watery diarrhoea and moderate to severe dehydration compared the efficacy of azithromycin (1 gram) single dose and Norfloxacin (400 mg) twice daily for three days in treating cholera. Data were analysed for 64 patients who were stool culture positive for Vibrio cholerae. In conjunction with rehydration therapy, 32 patients received Azithromycin and 32 patients received Norfloxacin. Patients in the two treatment groups had comparable clinical characteristics on admission. CONCLUSIONS: Result shows Azithromycin and Norfloxacin has got almost similar efficacy in reducing stool output, duration of diarrhoea and fluid requirement in cholera positive cases.
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spelling pubmed-42896982015-01-16 Comparison between Single Dose Azithromycin and Six Doses, 3 Day Norfloxacin for Treatment of Cholera in Adult Bhattacharya, M. K. Kanungo, S Ramamurthy, T Rajendran, K Sinha, A Bhattacharya, A Sarkar, B. Sharma Int J Biomed Sci Original Article AIM: To evaluate the efficacy of single dose Azithromycin (1 gram) in treatment of cholera in adults. A randomized, controlled clinical trial on 120 adults with acute watery diarrhoea and moderate to severe dehydration compared the efficacy of azithromycin (1 gram) single dose and Norfloxacin (400 mg) twice daily for three days in treating cholera. Data were analysed for 64 patients who were stool culture positive for Vibrio cholerae. In conjunction with rehydration therapy, 32 patients received Azithromycin and 32 patients received Norfloxacin. Patients in the two treatment groups had comparable clinical characteristics on admission. CONCLUSIONS: Result shows Azithromycin and Norfloxacin has got almost similar efficacy in reducing stool output, duration of diarrhoea and fluid requirement in cholera positive cases. Master Publishing Group 2014-12 /pmc/articles/PMC4289698/ /pubmed/25598755 Text en © M. K. Bhattacharya et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Bhattacharya, M. K.
Kanungo, S
Ramamurthy, T
Rajendran, K
Sinha, A
Bhattacharya, A
Sarkar, B. Sharma
Comparison between Single Dose Azithromycin and Six Doses, 3 Day Norfloxacin for Treatment of Cholera in Adult
title Comparison between Single Dose Azithromycin and Six Doses, 3 Day Norfloxacin for Treatment of Cholera in Adult
title_full Comparison between Single Dose Azithromycin and Six Doses, 3 Day Norfloxacin for Treatment of Cholera in Adult
title_fullStr Comparison between Single Dose Azithromycin and Six Doses, 3 Day Norfloxacin for Treatment of Cholera in Adult
title_full_unstemmed Comparison between Single Dose Azithromycin and Six Doses, 3 Day Norfloxacin for Treatment of Cholera in Adult
title_short Comparison between Single Dose Azithromycin and Six Doses, 3 Day Norfloxacin for Treatment of Cholera in Adult
title_sort comparison between single dose azithromycin and six doses, 3 day norfloxacin for treatment of cholera in adult
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289698/
https://www.ncbi.nlm.nih.gov/pubmed/25598755
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