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Solitary hypervascular liver metastasis from neuroendocrine tumor mimicking hepatocellular cancer: All that glitters is not gold

Neuroendocrine tumor metastases to the liver can mimic primary hepatocellular carcinoma (HCC) on imaging, cytology, and core biopsy. We present a case study along with the literature review of a patient who presented as a solitary liver mass mimicking HCC and subsequently underwent a partial hepatec...

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Autores principales: Laroia, Shalini Thapar, Sasturkar, Shridhar, Rastogi, Archana, Pamecha, Viniyendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290065/
https://www.ncbi.nlm.nih.gov/pubmed/25589805
http://dx.doi.org/10.4103/0972-3919.147535
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author Laroia, Shalini Thapar
Sasturkar, Shridhar
Rastogi, Archana
Pamecha, Viniyendra
author_facet Laroia, Shalini Thapar
Sasturkar, Shridhar
Rastogi, Archana
Pamecha, Viniyendra
author_sort Laroia, Shalini Thapar
collection PubMed
description Neuroendocrine tumor metastases to the liver can mimic primary hepatocellular carcinoma (HCC) on imaging, cytology, and core biopsy. We present a case study along with the literature review of a patient who presented as a solitary liver mass mimicking HCC and subsequently underwent a partial hepatectomy. The histopathology and immunohistochemisrty of the resected specimen revealed metastatic neuroendocrine carcinoma. Positron emission tomography (PET) scan with (68)Ga-DOTA-NaI-octreotide ((68)Ga-DOTANOC) localized the primary tumor in the ileum. A curative follow-up surgery for resection of the small bowel containing the primary tumor was carried out. This case illustrates the shortcomings of routine imaging methods, utility of immunocytochemistry and the importance of (68)Ga-DOTANOC PET in determining the metastatic spread as well as the origin of neuroendocrine tumors (NETs). This case report attempts to highlight the current imaging paradigms and management strategy of midgut and other NET's at the point of detection, staging and follow-up.
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spelling pubmed-42900652015-01-14 Solitary hypervascular liver metastasis from neuroendocrine tumor mimicking hepatocellular cancer: All that glitters is not gold Laroia, Shalini Thapar Sasturkar, Shridhar Rastogi, Archana Pamecha, Viniyendra Indian J Nucl Med Case Report Neuroendocrine tumor metastases to the liver can mimic primary hepatocellular carcinoma (HCC) on imaging, cytology, and core biopsy. We present a case study along with the literature review of a patient who presented as a solitary liver mass mimicking HCC and subsequently underwent a partial hepatectomy. The histopathology and immunohistochemisrty of the resected specimen revealed metastatic neuroendocrine carcinoma. Positron emission tomography (PET) scan with (68)Ga-DOTA-NaI-octreotide ((68)Ga-DOTANOC) localized the primary tumor in the ileum. A curative follow-up surgery for resection of the small bowel containing the primary tumor was carried out. This case illustrates the shortcomings of routine imaging methods, utility of immunocytochemistry and the importance of (68)Ga-DOTANOC PET in determining the metastatic spread as well as the origin of neuroendocrine tumors (NETs). This case report attempts to highlight the current imaging paradigms and management strategy of midgut and other NET's at the point of detection, staging and follow-up. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4290065/ /pubmed/25589805 http://dx.doi.org/10.4103/0972-3919.147535 Text en Copyright: © Indian Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Laroia, Shalini Thapar
Sasturkar, Shridhar
Rastogi, Archana
Pamecha, Viniyendra
Solitary hypervascular liver metastasis from neuroendocrine tumor mimicking hepatocellular cancer: All that glitters is not gold
title Solitary hypervascular liver metastasis from neuroendocrine tumor mimicking hepatocellular cancer: All that glitters is not gold
title_full Solitary hypervascular liver metastasis from neuroendocrine tumor mimicking hepatocellular cancer: All that glitters is not gold
title_fullStr Solitary hypervascular liver metastasis from neuroendocrine tumor mimicking hepatocellular cancer: All that glitters is not gold
title_full_unstemmed Solitary hypervascular liver metastasis from neuroendocrine tumor mimicking hepatocellular cancer: All that glitters is not gold
title_short Solitary hypervascular liver metastasis from neuroendocrine tumor mimicking hepatocellular cancer: All that glitters is not gold
title_sort solitary hypervascular liver metastasis from neuroendocrine tumor mimicking hepatocellular cancer: all that glitters is not gold
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290065/
https://www.ncbi.nlm.nih.gov/pubmed/25589805
http://dx.doi.org/10.4103/0972-3919.147535
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