Multiplex Imaging and Cellular Target Identification of Kinase Inhibitors via an Affinity-Based Proteome Profiling Approach

MLN8237 is a highly potent and presumably selective inhibitor of Aurora kinase A (AKA) and has shown promising antitumor activities. Like other kinase inhibitors which target the ATP-binding site of kinases, MLN8237 might be expected to have potential cellular off-targets. Herein, we report the firs...

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Detalles Bibliográficos
Autores principales: Su, Ying, Pan, Sijun, Li, Zhengqiu, Li, Lin, Wu, Xiaoyuan, Hao, Piliang, Sze, Siu Kwan, Yao, Shao Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290084/
https://www.ncbi.nlm.nih.gov/pubmed/25579846
http://dx.doi.org/10.1038/srep07724

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