Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo-keto reductase

BACKGROUND AND PURPOSE: Fluoxetine, a selective serotonin reuptake inhibitor, elevates brain concentrations of the neuroactive progesterone metabolite allopregnanolone, an effect suggested to underlie its use in the treatment of premenstrual dysphoria. One report showed fluoxetine to activate the al...

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Detalles Bibliográficos
Autores principales: Fry, J P, Li, K Y, Devall, A J, Cockcroft, S, Honour, J W, Lovick, T A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290723/
https://www.ncbi.nlm.nih.gov/pubmed/25161074
http://dx.doi.org/10.1111/bph.12891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290723/
https://www.ncbi.nlm.nih.gov/pubmed/25161074
http://dx.doi.org/10.1111/bph.12891

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