Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design

OBJECTIVES: Enterobacteriaceae have multiple efflux pumps that confer intrinsic resistance to antibiotics. AcrB mediates clinically relevant multidrug resistance and is required for virulence and biofilm formation, making it an attractive target for the design of inhibitors. The aim of this study wa...

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Detalles Bibliográficos
Autores principales: Blair, Jessica M. A., Smith, Helen E., Ricci, Vito, Lawler, Amelia J., Thompson, Louisa J., Piddock, Laura J. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291234/
https://www.ncbi.nlm.nih.gov/pubmed/25288678
http://dx.doi.org/10.1093/jac/dku380

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