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A Continuous Enzyme-Coupled Assay for Triphosphohydrolase Activity of HIV-1 Restriction Factor SAMHD1

The development of deoxynucleoside triphosphate (dNTP)-based drugs requires a quantitative understanding of any inhibition, activation, or hydrolysis by off-target cellular enzymes. SAMHD1 is a regulatory dNTP-triphosphohydrolase that inhibits HIV-1 replication in human myeloid cells. We describe he...

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Detalles Bibliográficos
Autores principales:	Arnold, Laurence H., Kunzelmann, Simone, Webb, Martin R., Taylor, Ian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2014
Materias:	Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291348/ https://www.ncbi.nlm.nih.gov/pubmed/25331707 http://dx.doi.org/10.1128/AAC.03903-14

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