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Expression of MTAP Inhibits Tumor-Related Phenotypes in HT1080 Cells via a Mechanism Unrelated to Its Enzymatic Function

Methylthioadenosine Phosphorylase (MTAP) is a tumor suppressor gene that is frequently deleted in human cancers and encodes an enzyme responsible for the catabolism of the polyamine byproduct 5′deoxy-5′-methylthioadenosine (MTA). To elucidate the mechanism by which MTAP inhibits tumor formation, we...

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Detalles Bibliográficos
Autores principales:	Tang, Baiqing, Kadariya, Yuwaraj, Chen, Yibai, Slifker, Michael, Kruger, Warren D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2014
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291467/ https://www.ncbi.nlm.nih.gov/pubmed/25387827 http://dx.doi.org/10.1534/g3.114.014555

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