mTOR inhibition rescues osteopenia in mice with systemic sclerosis

Fibrillin-1 (FBN1) deficiency-induced systemic sclerosis is attributed to elevation of interleukin-4 (IL4) and TGF-β, but the mechanism underlying FBN1 deficiency–associated osteopenia is not fully understood. We show that bone marrow mesenchymal stem cells (BMMSCs) from FBN1-deficient (Fbn1(+/−)) m...

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Detalles Bibliográficos
Autores principales: Chen, Chider, Akiyama, Kentaro, Wang, Dandan, Xu, Xingtian, Li, Bei, Moshaverinia, Alireza, Brombacher, Frank, Sun, Lingyun, Shi, Songtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291526/
https://www.ncbi.nlm.nih.gov/pubmed/25534817
http://dx.doi.org/10.1084/jem.20140643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291526/
https://www.ncbi.nlm.nih.gov/pubmed/25534817
http://dx.doi.org/10.1084/jem.20140643

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