A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy

Kidney allograft rejection is associated with infiltration of inflammatory CD11b+ leukocytes. A CD11b agonist leukadherin-1 (LA1) increases leukocyte adhesion, preventing their transmigration and tissue recruitment in vivo. Here, we test the extent to which LA1-mediated activation of CD11b/CD18 enha...

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Detalles Bibliográficos
Autores principales: Khan, Samia Q., Guo, Lingling, Cimbaluk, David J., Elshabrawy, Hatem, Faridi, Mohd Hafeez, Jolly, Meenakshi, George, James F., Agarwal, Anupam, Gupta, Vineet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291902/
https://www.ncbi.nlm.nih.gov/pubmed/25593918
http://dx.doi.org/10.3389/fmed.2014.00045

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