Intraventricular Ciprofloxacin Usage in Treatment of Multidrug-Resistant Central Nervous System Infections: Report of Four Cases

In recent years, multidrug-resistant microorganisms appear as important nosocomial pathogens which treatment is quite difficult. As sufficient drug levels could not be achieved in cerebrospinal fluid during intravenous antibiotic therapy for central nervous system infections and due to multidrug-res...

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Autores principales: Karaaslan, Ayşe, Kadayifçi, Eda Kepenekli, Turel, Ozden, Toprak, Demet Gedikbaşi, Soysal, Ahmet, Bakir, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292061/
https://www.ncbi.nlm.nih.gov/pubmed/25635219
http://dx.doi.org/10.4081/pr.2014.5619
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author Karaaslan, Ayşe
Kadayifçi, Eda Kepenekli
Turel, Ozden
Toprak, Demet Gedikbaşi
Soysal, Ahmet
Bakir, Mustafa
author_facet Karaaslan, Ayşe
Kadayifçi, Eda Kepenekli
Turel, Ozden
Toprak, Demet Gedikbaşi
Soysal, Ahmet
Bakir, Mustafa
author_sort Karaaslan, Ayşe
collection PubMed
description In recent years, multidrug-resistant microorganisms appear as important nosocomial pathogens which treatment is quite difficult. As sufficient drug levels could not be achieved in cerebrospinal fluid during intravenous antibiotic therapy for central nervous system infections and due to multidrug-resistance treatment alternatives are limited. In this study, four cases of central nervous system infections due to multidrug-resistant microorganisms who were successfully treated with removal of the devices and intraventricular ciprofloxacin are presented. In conclusion, intraventricular ciprofloxacin can be used for treatment of central nervous system infections if the causative microorganism is sensitive to the drug and no other alternative therapy is available.
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spelling pubmed-42920612015-01-29 Intraventricular Ciprofloxacin Usage in Treatment of Multidrug-Resistant Central Nervous System Infections: Report of Four Cases Karaaslan, Ayşe Kadayifçi, Eda Kepenekli Turel, Ozden Toprak, Demet Gedikbaşi Soysal, Ahmet Bakir, Mustafa Pediatr Rep Case Report In recent years, multidrug-resistant microorganisms appear as important nosocomial pathogens which treatment is quite difficult. As sufficient drug levels could not be achieved in cerebrospinal fluid during intravenous antibiotic therapy for central nervous system infections and due to multidrug-resistance treatment alternatives are limited. In this study, four cases of central nervous system infections due to multidrug-resistant microorganisms who were successfully treated with removal of the devices and intraventricular ciprofloxacin are presented. In conclusion, intraventricular ciprofloxacin can be used for treatment of central nervous system infections if the causative microorganism is sensitive to the drug and no other alternative therapy is available. PAGEPress Publications, Pavia, Italy 2014-12-12 /pmc/articles/PMC4292061/ /pubmed/25635219 http://dx.doi.org/10.4081/pr.2014.5619 Text en ©Copyright A. Karaaslan et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Karaaslan, Ayşe
Kadayifçi, Eda Kepenekli
Turel, Ozden
Toprak, Demet Gedikbaşi
Soysal, Ahmet
Bakir, Mustafa
Intraventricular Ciprofloxacin Usage in Treatment of Multidrug-Resistant Central Nervous System Infections: Report of Four Cases
title Intraventricular Ciprofloxacin Usage in Treatment of Multidrug-Resistant Central Nervous System Infections: Report of Four Cases
title_full Intraventricular Ciprofloxacin Usage in Treatment of Multidrug-Resistant Central Nervous System Infections: Report of Four Cases
title_fullStr Intraventricular Ciprofloxacin Usage in Treatment of Multidrug-Resistant Central Nervous System Infections: Report of Four Cases
title_full_unstemmed Intraventricular Ciprofloxacin Usage in Treatment of Multidrug-Resistant Central Nervous System Infections: Report of Four Cases
title_short Intraventricular Ciprofloxacin Usage in Treatment of Multidrug-Resistant Central Nervous System Infections: Report of Four Cases
title_sort intraventricular ciprofloxacin usage in treatment of multidrug-resistant central nervous system infections: report of four cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292061/
https://www.ncbi.nlm.nih.gov/pubmed/25635219
http://dx.doi.org/10.4081/pr.2014.5619
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