Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state...

Descripción completa

Detalles Bibliográficos
Autores principales: Mao, Chih-Ping, Wu, Tc, Song, Kwon-Ho, Kim, Tae Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292413/
https://www.ncbi.nlm.nih.gov/pubmed/25610734
http://dx.doi.org/10.4161/21624011.2014.947871
_version_ 1782352480516964352
author Mao, Chih-Ping
Wu, Tc
Song, Kwon-Ho
Kim, Tae Woo
author_facet Mao, Chih-Ping
Wu, Tc
Song, Kwon-Ho
Kim, Tae Woo
author_sort Mao, Chih-Ping
collection PubMed
description Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.
format Online
Article
Text
id pubmed-4292413
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-42924132015-07-03 Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion Mao, Chih-Ping Wu, Tc Song, Kwon-Ho Kim, Tae Woo Oncoimmunology Author's View Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer. Taylor & Francis 2014-07-03 /pmc/articles/PMC4292413/ /pubmed/25610734 http://dx.doi.org/10.4161/21624011.2014.947871 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Mao, Chih-Ping
Wu, Tc
Song, Kwon-Ho
Kim, Tae Woo
Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion
title Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion
title_full Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion
title_fullStr Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion
title_full_unstemmed Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion
title_short Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion
title_sort immune-mediated tumor evolution: nanog links the emergence of a stem like cancer cell state and immune evasion
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292413/
https://www.ncbi.nlm.nih.gov/pubmed/25610734
http://dx.doi.org/10.4161/21624011.2014.947871
work_keys_str_mv AT maochihping immunemediatedtumorevolutionnanoglinkstheemergenceofastemlikecancercellstateandimmuneevasion
AT wutc immunemediatedtumorevolutionnanoglinkstheemergenceofastemlikecancercellstateandimmuneevasion
AT songkwonho immunemediatedtumorevolutionnanoglinkstheemergenceofastemlikecancercellstateandimmuneevasion
AT kimtaewoo immunemediatedtumorevolutionnanoglinkstheemergenceofastemlikecancercellstateandimmuneevasion

Ejemplares similares