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Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion
Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292413/ https://www.ncbi.nlm.nih.gov/pubmed/25610734 http://dx.doi.org/10.4161/21624011.2014.947871 |