Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients

Immune escape mechanisms are prevalent in tumors, while their influence on the potency of antitumor immunotherapy has yet to be distinguished. We recently showed that increased numbers of intratumoral T cells rather than immune-escape-mechanisms significantly correlated with clinical outcome of adva...

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Detalles Bibliográficos
Autores principales: Tjin, Esther P M, Luiten, Rosalie M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292520/
https://www.ncbi.nlm.nih.gov/pubmed/25941603
http://dx.doi.org/10.4161/21624011.2014.954862
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author Tjin, Esther P M
Luiten, Rosalie M
author_facet Tjin, Esther P M
Luiten, Rosalie M
author_sort Tjin, Esther P M
collection PubMed
description Immune escape mechanisms are prevalent in tumors, while their influence on the potency of antitumor immunotherapy has yet to be distinguished. We recently showed that increased numbers of intratumoral T cells rather than immune-escape-mechanisms significantly correlated with clinical outcome of advanced melanoma patients to subsequent autologous tumor cell vaccination. Our data emphasize the therapeutic relevance of tumor-infiltrating T cells for the clinical outcome.
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spelling pubmed-42925202015-12-10 Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients Tjin, Esther P M Luiten, Rosalie M Oncoimmunology Article Immune escape mechanisms are prevalent in tumors, while their influence on the potency of antitumor immunotherapy has yet to be distinguished. We recently showed that increased numbers of intratumoral T cells rather than immune-escape-mechanisms significantly correlated with clinical outcome of advanced melanoma patients to subsequent autologous tumor cell vaccination. Our data emphasize the therapeutic relevance of tumor-infiltrating T cells for the clinical outcome. Taylor & Francis 2014-12-10 /pmc/articles/PMC4292520/ /pubmed/25941603 http://dx.doi.org/10.4161/21624011.2014.954862 Text en © 2014 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Article
Tjin, Esther P M
Luiten, Rosalie M
Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients
title Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients
title_full Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients
title_fullStr Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients
title_full_unstemmed Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients
title_short Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients
title_sort tumor-infiltrating t-cells: important players in clinical outcome of advanced melanoma patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292520/
https://www.ncbi.nlm.nih.gov/pubmed/25941603
http://dx.doi.org/10.4161/21624011.2014.954862
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