Cargando…
The pancreatic cancer microenvironment: an immunologic battleground
Recent studies of human pancreatic cancer challenge the mouse model-derived notion that the pancreas is a site of immune privilege. A heavy infiltration of CD8(+) T cells expressing programmed cell death 1 (PD-1) and smaller numbers of myeloid cells and regulatory T cells provides rationale for the...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292569/ https://www.ncbi.nlm.nih.gov/pubmed/25610740 http://dx.doi.org/10.4161/21624011.2014.950171 |
| _version_ | 1782352502472048640 |
|---|---|
| author | Pillarisetty, Venu G |
| author_facet | Pillarisetty, Venu G |
| author_sort | Pillarisetty, Venu G |
| collection | PubMed |
| description | Recent studies of human pancreatic cancer challenge the mouse model-derived notion that the pancreas is a site of immune privilege. A heavy infiltration of CD8(+) T cells expressing programmed cell death 1 (PD-1) and smaller numbers of myeloid cells and regulatory T cells provides rationale for the clinical evaluation of immune checkpoint inhibition as a pancreatic cancer therapeutic strategy. |
| format | Online Article Text |
| id | pubmed-4292569 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42925692015-08-03 The pancreatic cancer microenvironment: an immunologic battleground Pillarisetty, Venu G Oncoimmunology AUTHOR'S View Recent studies of human pancreatic cancer challenge the mouse model-derived notion that the pancreas is a site of immune privilege. A heavy infiltration of CD8(+) T cells expressing programmed cell death 1 (PD-1) and smaller numbers of myeloid cells and regulatory T cells provides rationale for the clinical evaluation of immune checkpoint inhibition as a pancreatic cancer therapeutic strategy. Taylor & Francis 2014-08-03 /pmc/articles/PMC4292569/ /pubmed/25610740 http://dx.doi.org/10.4161/21624011.2014.950171 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
| spellingShingle | AUTHOR'S View Pillarisetty, Venu G The pancreatic cancer microenvironment: an immunologic battleground |
| title | The pancreatic cancer microenvironment: an immunologic battleground |
| title_full | The pancreatic cancer microenvironment: an immunologic battleground |
| title_fullStr | The pancreatic cancer microenvironment: an immunologic battleground |
| title_full_unstemmed | The pancreatic cancer microenvironment: an immunologic battleground |
| title_short | The pancreatic cancer microenvironment: an immunologic battleground |
| title_sort | pancreatic cancer microenvironment: an immunologic battleground |
| topic | AUTHOR'S View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292569/ https://www.ncbi.nlm.nih.gov/pubmed/25610740 http://dx.doi.org/10.4161/21624011.2014.950171 |
| work_keys_str_mv | AT pillarisettyvenug thepancreaticcancermicroenvironmentanimmunologicbattleground AT pillarisettyvenug pancreaticcancermicroenvironmentanimmunologicbattleground |