Cargando…
Mathematical models of electrical activity of the pancreatic β-cell: A physiological review
Mathematical modeling of the electrical activity of the pancreatic β-cell has been extremely important for understanding the cellular mechanisms involved in glucose-stimulated insulin secretion. Several models have been proposed over the last 30 y, growing in complexity as experimental evidence of t...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292577/ https://www.ncbi.nlm.nih.gov/pubmed/25322829 http://dx.doi.org/10.4161/19382014.2014.949195 |
_version_ | 1782352503880286208 |
---|---|
author | Félix-Martínez, Gerardo J Godínez-Fernández, J Rafael |
author_facet | Félix-Martínez, Gerardo J Godínez-Fernández, J Rafael |
author_sort | Félix-Martínez, Gerardo J |
collection | PubMed |
description | Mathematical modeling of the electrical activity of the pancreatic β-cell has been extremely important for understanding the cellular mechanisms involved in glucose-stimulated insulin secretion. Several models have been proposed over the last 30 y, growing in complexity as experimental evidence of the cellular mechanisms involved has become available. Almost all the models have been developed based on experimental data from rodents. However, given the many important differences between species, models of human β-cells have recently been developed. This review summarizes how modeling of β-cells has evolved, highlighting the proposed physiological mechanisms underlying β-cell electrical activity. |
format | Online Article Text |
id | pubmed-4292577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-42925772015-10-31 Mathematical models of electrical activity of the pancreatic β-cell: A physiological review Félix-Martínez, Gerardo J Godínez-Fernández, J Rafael Islets Review Mathematical modeling of the electrical activity of the pancreatic β-cell has been extremely important for understanding the cellular mechanisms involved in glucose-stimulated insulin secretion. Several models have been proposed over the last 30 y, growing in complexity as experimental evidence of the cellular mechanisms involved has become available. Almost all the models have been developed based on experimental data from rodents. However, given the many important differences between species, models of human β-cells have recently been developed. This review summarizes how modeling of β-cells has evolved, highlighting the proposed physiological mechanisms underlying β-cell electrical activity. Taylor & Francis 2014-10-31 /pmc/articles/PMC4292577/ /pubmed/25322829 http://dx.doi.org/10.4161/19382014.2014.949195 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Review Félix-Martínez, Gerardo J Godínez-Fernández, J Rafael Mathematical models of electrical activity of the pancreatic β-cell: A physiological review |
title | Mathematical models of electrical activity of the pancreatic β-cell: A
physiological review |
title_full | Mathematical models of electrical activity of the pancreatic β-cell: A
physiological review |
title_fullStr | Mathematical models of electrical activity of the pancreatic β-cell: A
physiological review |
title_full_unstemmed | Mathematical models of electrical activity of the pancreatic β-cell: A
physiological review |
title_short | Mathematical models of electrical activity of the pancreatic β-cell: A
physiological review |
title_sort | mathematical models of electrical activity of the pancreatic β-cell: a
physiological review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292577/ https://www.ncbi.nlm.nih.gov/pubmed/25322829 http://dx.doi.org/10.4161/19382014.2014.949195 |
work_keys_str_mv | AT felixmartinezgerardoj mathematicalmodelsofelectricalactivityofthepancreaticbcellaphysiologicalreview AT godinezfernandezjrafael mathematicalmodelsofelectricalactivityofthepancreaticbcellaphysiologicalreview |