Contribution of non-reference alleles in mtDNA of Alzheimer's disease patients

Many observations suggest that mutations of mitochondrial DNA (mtDNA) could be responsible for the neurodegenerative changes of Alzheimer's disease (AD). Here we examined the signal intensity of the four alleles of each mtDNA nucleotide position (np) in whole blood of AD patients and age-matche...

Descripción completa

Detalles Bibliográficos
Autores principales: Casoli, Tiziana, Di Stefano, Giuseppina, Spazzafumo, Liana, Balietti, Marta, Giorgetti, Belinda, Giuli, Cinzia, Postacchini, Demetrio, Fattoretti, Patrizia, Conti, Fiorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292745/
https://www.ncbi.nlm.nih.gov/pubmed/25590040
http://dx.doi.org/10.1002/acn3.42
Descripción
Sumario:Many observations suggest that mutations of mitochondrial DNA (mtDNA) could be responsible for the neurodegenerative changes of Alzheimer's disease (AD). Here we examined the signal intensity of the four alleles of each mtDNA nucleotide position (np) in whole blood of AD patients and age-matched controls using MitoChip v2.0 array. Our analysis identified 270 significantly different nps which, with one exception, showed an increased contribution of non-reference alleles in AD patients. Principal component analysis (PCA) and cluster analysis showed that five of these nps could discriminate AD from control subjects with 80% of cases correctly classified. Our data support the hypothesis of mtDNA alterations as an important factor in the etiology of AD.

Ejemplares similares