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Spinal cord atrophy in early Huntington's disease
Despite evidence for spinal cord involvement, it remains unclear whether spinal cord atrophy exists in early Huntington's disease. We studied magnetic resonance images, covering both brain and upper cervical cord, in two cohorts of Huntington's patients and in one cohort of Alzheimer'...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292748/ https://www.ncbi.nlm.nih.gov/pubmed/25590043 http://dx.doi.org/10.1002/acn3.52 |
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author | Mühlau, Mark Engl, Christina Boucard, Christine C Schmidt, Paul Biberacher, Viola Görsch, Isabel Sorg, Christian Wohlschläger, Afra Zimmer, Claus Hemmer, Bernhard Weindl, Adolph |
author_facet | Mühlau, Mark Engl, Christina Boucard, Christine C Schmidt, Paul Biberacher, Viola Görsch, Isabel Sorg, Christian Wohlschläger, Afra Zimmer, Claus Hemmer, Bernhard Weindl, Adolph |
author_sort | Mühlau, Mark |
collection | PubMed |
description | Despite evidence for spinal cord involvement, it remains unclear whether spinal cord atrophy exists in early Huntington's disease. We studied magnetic resonance images, covering both brain and upper cervical cord, in two cohorts of Huntington's patients and in one cohort of Alzheimer's patients. All cohorts included healthy controls comparable with regard to age and gender. We found significant spinal cord atrophy in both cohorts of Huntington's patients but not in the cohort of Alzheimer's patients. Furthermore, spinal cord atrophy correlated with motor symptoms indicating that spinal cord atrophy occurs in the clinical stages and does not result from abnormal development. |
format | Online Article Text |
id | pubmed-4292748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42927482015-01-14 Spinal cord atrophy in early Huntington's disease Mühlau, Mark Engl, Christina Boucard, Christine C Schmidt, Paul Biberacher, Viola Görsch, Isabel Sorg, Christian Wohlschläger, Afra Zimmer, Claus Hemmer, Bernhard Weindl, Adolph Ann Clin Transl Neurol Brief Communications Despite evidence for spinal cord involvement, it remains unclear whether spinal cord atrophy exists in early Huntington's disease. We studied magnetic resonance images, covering both brain and upper cervical cord, in two cohorts of Huntington's patients and in one cohort of Alzheimer's patients. All cohorts included healthy controls comparable with regard to age and gender. We found significant spinal cord atrophy in both cohorts of Huntington's patients but not in the cohort of Alzheimer's patients. Furthermore, spinal cord atrophy correlated with motor symptoms indicating that spinal cord atrophy occurs in the clinical stages and does not result from abnormal development. Blackwell Publishing Ltd 2014-04 2014-03-24 /pmc/articles/PMC4292748/ /pubmed/25590043 http://dx.doi.org/10.1002/acn3.52 Text en © 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Brief Communications Mühlau, Mark Engl, Christina Boucard, Christine C Schmidt, Paul Biberacher, Viola Görsch, Isabel Sorg, Christian Wohlschläger, Afra Zimmer, Claus Hemmer, Bernhard Weindl, Adolph Spinal cord atrophy in early Huntington's disease |
title | Spinal cord atrophy in early Huntington's disease |
title_full | Spinal cord atrophy in early Huntington's disease |
title_fullStr | Spinal cord atrophy in early Huntington's disease |
title_full_unstemmed | Spinal cord atrophy in early Huntington's disease |
title_short | Spinal cord atrophy in early Huntington's disease |
title_sort | spinal cord atrophy in early huntington's disease |
topic | Brief Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292748/ https://www.ncbi.nlm.nih.gov/pubmed/25590043 http://dx.doi.org/10.1002/acn3.52 |
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