Alzheimery's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

Here, we leverage a unique collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We find that the level of methylation at 71 of the 415,848 interrogated CpGs is significantly associated with th...

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Detalles Bibliográficos
Autores principales: De Jager, PL, Srivastava, G, Lunnon, K, Burgess, J, Schalkwyk, LC, Yu, L, Eaton, ML, Keenan, BT, Ernst, J, McCabe, C, Tang, A, Raj, T, Replogle, J, Brodeur, W, Gabriel, S, Chai, HS, Younkin, C, Younkin, SG, Zou, F, Szyf, M, Epstein, CB, Schneider, JA, Bernstein, BE, Meissner, A, Ertekin-Taner, N, Chibnik, LB, Kellis, M, Mill, J, Bennett, DA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292795/
https://www.ncbi.nlm.nih.gov/pubmed/25129075
http://dx.doi.org/10.1038/nn.3786

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