Cargando…

Genomic investigation of etiologic heterogeneity: methodologic challenges

BACKGROUND: The etiologic heterogeneity of cancer has traditionally been investigated by comparing risk factor frequencies within candidate sub-types, defined for example by histology or by distinct tumor markers of interest. Increasingly tumors are being profiled for molecular features much more ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Begg, Colin B, Seshan, Venkatraman E, Zabor, Emily C, Furberg, Helena, Arora, Arshi, Shen, Ronglai, Maranchie, Jodi K, Nielsen, Matthew E, Rathmell, W Kimryn, Signoretti, Sabina, Tamboli, Pheroze, Karam, Jose A, Choueiri, Toni K, Hakimi, A Ari, Hsieh, James J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292824/ https://www.ncbi.nlm.nih.gov/pubmed/25532962 http://dx.doi.org/10.1186/1471-2288-14-138

Ejemplares similares

Identifying Etiologically Distinct Sub-Types of Cancer: A Demonstration Project Involving Breast Cancer
por: Begg, Colin B, et al.
Publicado: (2015)

Expression of Ror2 Mediates Invasive Phenotypes in Renal Cell Carcinoma
por: Rasmussen, Neal R., et al.
Publicado: (2014)

Pan-cancer identification of clinically relevant genomic subtypes using outcome-weighted integrative clustering
por: Arora, Arshi, et al.
Publicado: (2020)

Using somatic variant richness to mine signals from rare variants in the cancer genome
por: Chakraborty, Saptarshi, et al.
Publicado: (2019)

FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing
por: Shen, Ronglai, et al.
Publicado: (2016)

In Reply
por: de Velasco, Guillermo, et al.
Publicado: (2017)

An EM algorithm to improve the estimation of the probability of clonal relatedness of pairs of tumors in cancer patients
por: Mauguen, Audrey, et al.
Publicado: (2019)

Systematic Review: ClearCode 34 – A Validated Prognostic Signature in Clear Cell Renal Cell Carcinoma (ccRCC)
por: Ghatalia, Pooja, et al.
Publicado: (2018)

The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy
por: Lim, Aaron R, et al.
Publicado: (2020)

Correlation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinoma
por: Mullane, Stephanie A., et al.
Publicado: (2016)

Untangling ccRCC prognosis with SLINKY
por: Reinfeld, Bradley I., et al.
Publicado: (2017)

COVID-19 impact on early career investigators: a call for action
por: Levine, Ross L., et al.
Publicado: (2020)

A generative adversarial approach to facilitate archival-quality histopathologic diagnoses from frozen tissue sections
por: Falahkheirkhah, Kianoush, et al.
Publicado: (2022)

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
por: Ricketts, Christopher J., et al.
Publicado: (2018)

Integrative Subtype Discovery in Glioblastoma Using iCluster
por: Shen, Ronglai, et al.
Publicado: (2012)

Renal cell carcinoma
por: Jonasch, Eric, et al.
Publicado: (2014)

The therapeutic implications of immunosuppressive tumor aerobic glycolysis
por: Reinfeld, Bradley I., et al.
Publicado: (2021)

Accounting for Delayed Entry in Analyses of Overall Survival in Clinico-Genomic Databases
por: Backenroth, Daniel, et al.
Publicado: (2022)

Contemporary approach to diagnosis and classification of renal cell carcinoma with mixed histologic features
por: Sircar, Kanishka, et al.
Publicado: (2013)

Targeted genomic landscape of metastases compared to primary tumours in clear cell metastatic renal cell carcinoma
por: de Velasco, Guillermo, et al.
Publicado: (2018)

Genomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies
por: Rathmell, Kimryn W., et al.
Publicado: (2015)

Invadopodia formation in blood clots: Not so SLUGgish after all
por: Knowles, Lynn M, et al.
Publicado: (2014)

HIF1α and HIF2α Exert Distinct Nutrient Preferences in Renal Cells
por: Arreola, Alexandra, et al.
Publicado: (2014)

Predicting Cancer Risk from Germline Whole-exome Sequencing Data Using a Novel Context-based Variant Aggregation Approach
por: Guan, Zoe, et al.
Publicado: (2023)

Collision tumor of the kidney composed of clear cell carcinoma and collecting duct carcinoma: report of a case with unusual morphology and clinical follow-up
por: Burch-Smith, Rhonda, et al.
Publicado: (2014)

VHL Type 2B Mutations Retain VBC Complex Form and Function
por: Hacker, Kathryn E., et al.
Publicado: (2008)

Modeling Clear Cell Renal Cell Carcinoma and Therapeutic Implications
por: Wolf, Melissa M., et al.
Publicado: (2020)

Multidrug Resistant Epididymitis Progressing to Testicular Infarct and Orchiectomy
por: Farber, Nicholas J., et al.
Publicado: (2013)

Examining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries
por: Begg, Colin B, et al.
Publicado: (2017)

Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis, and ATM-Mediated DNA Damage Response
por: DeSimone, Michelle C., et al.
Publicado: (2013)

Pan-urologic cancer genomic subtypes that transcend tissue of origin
por: Chen, Fengju, et al.
Publicado: (2017)

Integrative computational immunogenomic profiling of cortisol‐secreting adrenocortical carcinoma
por: Baechle, Jordan J., et al.
Publicado: (2021)

Update on vaccine development for renal cell cancer
por: Chi, Nina, et al.
Publicado: (2010)

Fibronectin Matrix Formation is a Prerequisite for Colonization of Kidney Tumor Cells in Fibrin
por: Knowles, Lynn M., et al.
Publicado: (2015)

Mitochondrial DNA copy number variation across human cancers
por: Reznik, Ed, et al.
Publicado: (2016)

Mining mutation contexts across the cancer genome to map tumor site of origin
por: Chakraborty, Saptarshi, et al.
Publicado: (2021)

Correction to: Outcomes based on plasma biomarkers in METEOR, a randomized phase 3 trial of cabozantinib vs everolimus in advanced renal cell carcinoma
por: Powles, Thomas, et al.
Publicado: (2021)

Outcomes based on plasma biomarkers in METEOR, a randomized phase 3 trial of cabozantinib vs everolimus in advanced renal cell carcinoma
por: Powles, Thomas, et al.
Publicado: (2021)

Mechanisms of acquired resistance to rapalogs in metastatic renal cell carcinoma
por: Hamieh, Lana, et al.
Publicado: (2018)

Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield from Lung, Liver, and Kidney Tumors: Implications for Cancer Genomics
por: Silk, Mikhail T., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_a590ru9gdq6sumv7lmevm14a2c