Cargando…

Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis

INTRODUCTION: Genetic susceptibility to complex diseases has been intensively studied during the last decade, yet only signals with small effect have been found leaving open the possibility that subgroups within complex traits show stronger association signals. In rheumatoid arthritis (RA), autoanti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Snir, Omri, Gomez-Cabrero, David, Montes, Ariana, Perez-Pampin, Eva, Gómez-Reino, Juan J, Seddighzadeh, Maria, Klich, Katharina U, Israelsson, Lena, Ding, Bo, Catrina, Anca I, Holmdahl, Rikard, Alfredsson, Lars, Klareskog, Lars, Tegnér, Jesper, Gonzalez, Antonio, Malmström, Vivianne, Padyukov, Leonid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292996/ https://www.ncbi.nlm.nih.gov/pubmed/25138370 http://dx.doi.org/10.1186/s13075-014-0414-3

Ejemplares similares

Implementation of the CDC translational informatics platform - from genetic variants to the national Swedish Rheumatology Quality Register
por: Abugessaisa, Imad, et al.
Publicado: (2013)

Systematic approach demonstrates enrichment of multiple interactions between non-HLA risk variants and HLA-DRB1 risk alleles in rheumatoid arthritis
por: Diaz-Gallo, Lina-Marcela, et al.
Publicado: (2018)

Interplay between alcohol, smoking and HLA genes in RA aetiology
por: Hedström, Anna Karin, et al.
Publicado: (2019)

Genetic variation in the serotonin receptor gene affects immune responses in rheumatoid arthritis
por: Snir, O, et al.
Publicado: (2013)

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity
por: Olsson, Lina M, et al.
Publicado: (2007)

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
por: Padyukov, Leonid, et al.
Publicado: (2010)

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
por: Amara, Khaled, et al.
Publicado: (2013)

Retraction: Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
por: Amara, Khaled, et al.
Publicado: (2019)

Haplotype-Specific Expression Analysis of MHC Class II Genes in Healthy Individuals and Rheumatoid Arthritis Patients
por: Houtman, Miranda, et al.
Publicado: (2021)

Analysis of Neuropeptide S Receptor Gene (NPSR1) Polymorphism in Rheumatoid Arthritis
por: D'Amato, Mauro, et al.
Publicado: (2010)

Complex Relationships of Smoking, HLA–DRB1 Genes, and Serologic Profiles in Patients With Early Rheumatoid Arthritis: Update From a Swedish Population‐Based Case–Control Study
por: Hedström, Anna Karin, et al.
Publicado: (2019)

PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis
por: Hisa, Kaori, et al.
Publicado: (2017)

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype
por: Terao, Chikashi, et al.
Publicado: (2019)

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype
por: Terao, Chikashi, et al.
Publicado: (2019)

Interaction Analysis between HLA-DRB1 Shared Epitope Alleles and MHC Class II Transactivator CIITA Gene with Regard to Risk of Rheumatoid Arthritis
por: Ronninger, Marcus, et al.
Publicado: (2012)

Affinity purified anti-citrullinated protein/peptide antibodies target antigens expressed in the rheumatoid joint
por: Ossipova, Elena, et al.
Publicado: (2014)

Genes and environment in arthritis: can RA be prevented?
por: Klareskog, Lars, et al.
Publicado: (2002)

Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice
por: Lindh, Ingrid, et al.
Publicado: (2014)

Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides
por: Hansson, Monika, et al.
Publicado: (2012)

HLA-DR, HLA-DQB1 and PTPN22 gene polymorphism: association with age at onset for autoimmune diabetes
por: Okruszko, Anna, et al.
Publicado: (2012)

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
por: Raychaudhuri, Soumya, et al.
Publicado: (2012)

Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis
por: Gagnon, France, et al.
Publicado: (2007)

Differences in the Spectrum of Anti–Citrullinated Protein Antibody Fine Specificities Between Malaysian and Swedish Patients With Rheumatoid Arthritis: Implications for Disease Pathogenesis
por: Too, Chun Lai, et al.
Publicado: (2016)

GEIRA: gene-environment and gene–gene interaction research application
por: Ding, Bo, et al.
Publicado: (2011)

Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA)
por: Too, Chun Lai, et al.
Publicado: (2012)

In vitro and ex vivo functional characterization of human HLA-DRB1∗04 restricted T cell receptors
por: Boddul, Sanjaykumar V., et al.
Publicado: (2021)

IFN-γ production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1(*)0401 and HLA-DQ8
por: Berg, Louise, et al.
Publicado: (2000)

Ultrasonographic Assessment of Enthesitis in HLA-B27 Positive Patients with Rheumatoid Arthritis, a Matched Case-Only Study
por: Mera-Varela, Antonio, et al.
Publicado: (2013)

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy – results from a Swedish cohort study
por: Jiang, Xia, et al.
Publicado: (2016)

Modulating co-stimulation: a rational strategy in the treatment of rheumatoid arthritis?
por: Malmström, Vivianne, et al.
Publicado: (2005)

A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis
por: Berglin, Ewa, et al.
Publicado: (2004)

Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology
por: Sherina, Natalia, et al.
Publicado: (2022)

Obesity‐Related Traits and the Development of Rheumatoid Arthritis: Evidence From Genetic Data
por: Tang, Bowen, et al.
Publicado: (2020)

Age at menarche, age at natural menopause, and risk of rheumatoid arthritis — a Mendelian randomization study
por: Zhu, Jingjing, et al.
Publicado: (2021)

Response to Comment “Sex-specific exposures and sex-combined outcomes in two-sample Mendelian randomization may mislead the causal inference” on “Age at menarche, age at natural menopause, and risk of rheumatoid arthritis—a Mendelian randomization study”
por: Zhu, Jingjing, et al.
Publicado: (2022)

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis
por: Gerstner, Christina, et al.
Publicado: (2020)

The spectrum of association in HLA region with rheumatoid arthritis in a diverse Asian population: evidence from the MyEIRA case-control study
por: Tan, Lay Kim, et al.
Publicado: (2021)

Recurrence of Graves’ Disease: What Genetics of HLA and PTPN22 Can Tell Us
por: Vejrazkova, Daniela, et al.
Publicado: (2021)

Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement
por: Kleinau, Sandra, et al.
Publicado: (1991)

Organic solvents and MS susceptibility: Interaction with MS risk HLA genes
por: Hedström, Anna Karin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_g3m3chr5he1l4hh141s3p2nub5