Pattern of secretion of pregnancy-associated plasma protein-A (PAPP-A) during pregnancies complicated by fetal aneuploidy, in vivo and in vitro

BACKGROUND: Pregnancy-associated placental protein-A (PAPP-A) is a metalloprotease which circulates as an hetero-tetramer in maternal blood. Its maternal serum concentration in fetal trisomy 21 is decreased during the first trimester, so that PAPP-A is a useful screening biomarker. However, the regu...

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Detalles Bibliográficos
Autores principales: Leguy, Marie Clémence, Brun, Stephanie, Pidoux, Guillaume, Salhi, Houria, Choiset, Agnes, Menet, Marie Claude, Gil, Sophie, Tsatsaris, Vassilis, Guibourdenche, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293003/
https://www.ncbi.nlm.nih.gov/pubmed/25543334
http://dx.doi.org/10.1186/1477-7827-12-129

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