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On the role of the endogenous opioid system in regulating epidermal homeostasis
The presence of functional opioid receptors on epidermal keratinocytes, with attendant regulation of keratinocyte proliferation and differentiation, indicate their novel role in maintaining epidermal homeostasis. Expression of proenkephalin precursors and neuropeptide products in the same compartmen...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293046/ https://www.ncbi.nlm.nih.gov/pubmed/25573044 http://dx.doi.org/10.1038/jid.2014.458 |
| Sumario: | The presence of functional opioid receptors on epidermal keratinocytes, with attendant regulation of keratinocyte proliferation and differentiation, indicate their novel role in maintaining epidermal homeostasis. Expression of proenkephalin precursors and neuropeptide products in the same compartment opens an opportunity to study the role of this endogenous opioid circuitry, with its regulators, in modulating epidermal barrier function. |
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