Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model

BACKGROUND: Squamous cell carcinoma (SCC) is a common skin cancer, and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted 5-aminolevulinic acid (ALA) delivery for topical photodynamic therapy (PDT) of cutaneous SCC. MATERIALS AND M...

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Autores principales: Wang, Xiaojie, Shi, Lei, Tu, Qingfeng, Wang, Hongwei, Zhang, Haiyan, Wang, Peiru, Zhang, Linglin, Huang, Zheng, Zhao, Feng, Luan, Hansen, Wang, Xiuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293366/
https://www.ncbi.nlm.nih.gov/pubmed/25609949
http://dx.doi.org/10.2147/IJN.S71245
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author Wang, Xiaojie
Shi, Lei
Tu, Qingfeng
Wang, Hongwei
Zhang, Haiyan
Wang, Peiru
Zhang, Linglin
Huang, Zheng
Zhao, Feng
Luan, Hansen
Wang, Xiuli
author_facet Wang, Xiaojie
Shi, Lei
Tu, Qingfeng
Wang, Hongwei
Zhang, Haiyan
Wang, Peiru
Zhang, Linglin
Huang, Zheng
Zhao, Feng
Luan, Hansen
Wang, Xiuli
author_sort Wang, Xiaojie
collection PubMed
description BACKGROUND: Squamous cell carcinoma (SCC) is a common skin cancer, and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted 5-aminolevulinic acid (ALA) delivery for topical photodynamic therapy (PDT) of cutaneous SCC. MATERIALS AND METHODS: Ultraviolet-induced cutaneous SCCs were established in hairless mice. ALA-loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NP-induced protoporphyrin IX fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined. RESULTS: PLGA NPs enhanced protoporphyrin IX production in SCC. ALA PLGA NP-mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC. CONCLUSION: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC.
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spelling pubmed-42933662015-01-21 Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model Wang, Xiaojie Shi, Lei Tu, Qingfeng Wang, Hongwei Zhang, Haiyan Wang, Peiru Zhang, Linglin Huang, Zheng Zhao, Feng Luan, Hansen Wang, Xiuli Int J Nanomedicine Original Research BACKGROUND: Squamous cell carcinoma (SCC) is a common skin cancer, and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted 5-aminolevulinic acid (ALA) delivery for topical photodynamic therapy (PDT) of cutaneous SCC. MATERIALS AND METHODS: Ultraviolet-induced cutaneous SCCs were established in hairless mice. ALA-loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NP-induced protoporphyrin IX fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined. RESULTS: PLGA NPs enhanced protoporphyrin IX production in SCC. ALA PLGA NP-mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC. CONCLUSION: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC. Dove Medical Press 2015-01-06 /pmc/articles/PMC4293366/ /pubmed/25609949 http://dx.doi.org/10.2147/IJN.S71245 Text en © 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Wang, Xiaojie
Shi, Lei
Tu, Qingfeng
Wang, Hongwei
Zhang, Haiyan
Wang, Peiru
Zhang, Linglin
Huang, Zheng
Zhao, Feng
Luan, Hansen
Wang, Xiuli
Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model
title Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model
title_full Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model
title_fullStr Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model
title_full_unstemmed Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model
title_short Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model
title_sort treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293366/
https://www.ncbi.nlm.nih.gov/pubmed/25609949
http://dx.doi.org/10.2147/IJN.S71245
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