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Cerebellar Directed Optogenetic Intervention Inhibits Spontaneous Hippocampal Seizures in a Mouse Model of Temporal Lobe Epilepsy1 2

Temporal lobe epilepsy is often medically refractory and new targets for intervention are needed. We used a mouse model of temporal lobe epilepsy, on-line seizure detection, and responsive optogenetic intervention to investigate the potential for cerebellar control of spontaneous temporal lobe seizu...

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Detalles Bibliográficos
Autores principales: Krook-Magnuson, Esther, Szabo, Gergely G., Armstrong, Caren, Oijala, Mikko, Soltesz, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293636/
https://www.ncbi.nlm.nih.gov/pubmed/25599088
http://dx.doi.org/10.1523/ENEURO.0005-14.2014