Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity

Tightly regulated Ca(2+) homeostasis is a prerequisite for proper cardiac function. To dissect the regulatory network of cardiac Ca(2+) handling, we performed a chemical suppressor screen on zebrafish tremblor embryos, which suffer from Ca(2+) extrusion defects. Efsevin was identified based on its p...

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Detalles Bibliográficos
Autores principales: Shimizu, Hirohito, Schredelseker, Johann, Huang, Jie, Lu, Kui, Naghdi, Shamim, Lu, Fei, Franklin, Sarah, Fiji, Hannah DG, Wang, Kevin, Zhu, Huanqi, Tian, Cheng, Lin, Billy, Nakano, Haruko, Ehrlich, Amy, Nakai, Junichi, Stieg, Adam Z, Gimzewski, James K, Nakano, Atsushi, Goldhaber, Joshua I, Vondriska, Thomas M, Hajnóczky, György, Kwon, Ohyun, Chen, Jau-Nian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293673/
https://www.ncbi.nlm.nih.gov/pubmed/25588501
http://dx.doi.org/10.7554/eLife.04801

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