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A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry

Natural products are increasingly being considered “critical and important” in drug discovery paradigms as a number of them such as camptothecin, penicillin, and vincristine serve as “lead molecules” for the discovery of potent compounds of therapeutic interests namely irinotecan, penicillin G, vinb...

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Detalles Bibliográficos
Autores principales: Sharma, Vikas, Sharma, Prabodh C., Kumar, Vipin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293674/
https://www.ncbi.nlm.nih.gov/pubmed/25685544
http://dx.doi.org/10.1016/j.jare.2014.11.002
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author Sharma, Vikas
Sharma, Prabodh C.
Kumar, Vipin
author_facet Sharma, Vikas
Sharma, Prabodh C.
Kumar, Vipin
author_sort Sharma, Vikas
collection PubMed
description Natural products are increasingly being considered “critical and important” in drug discovery paradigms as a number of them such as camptothecin, penicillin, and vincristine serve as “lead molecules” for the discovery of potent compounds of therapeutic interests namely irinotecan, penicillin G, vinblastine respectively. Derived compounds of pharmacological interests displayed a wide variety of activity viz. anticancer, anti-inflammatory, antimicrobial, anti-protozoal, etc.; when modifications or derivatizations are performed on a parent moiety representing the corresponding derivatives. Pyridoacridine is such a moiety which forms the basic structure of numerous medicinally important natural products such as, but not limited to, amphimedine, ascididemin, eilatin, and sampangine. Interestingly, synthetic analogues of natural pyridoacridine exhibit diverse pharmacological activities and in view of these, natural pyridoacridines can be considered as “lead compounds”. This review additionally provides a brief but critical account of inherent structure activity relationships among various subclasses of pyridoacridines. Furthermore, the current aspects and future prospects of natural pyridoacridines are detailed for further reference and consideration.
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spelling pubmed-42936742015-02-14 A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry Sharma, Vikas Sharma, Prabodh C. Kumar, Vipin J Adv Res Mini Review Natural products are increasingly being considered “critical and important” in drug discovery paradigms as a number of them such as camptothecin, penicillin, and vincristine serve as “lead molecules” for the discovery of potent compounds of therapeutic interests namely irinotecan, penicillin G, vinblastine respectively. Derived compounds of pharmacological interests displayed a wide variety of activity viz. anticancer, anti-inflammatory, antimicrobial, anti-protozoal, etc.; when modifications or derivatizations are performed on a parent moiety representing the corresponding derivatives. Pyridoacridine is such a moiety which forms the basic structure of numerous medicinally important natural products such as, but not limited to, amphimedine, ascididemin, eilatin, and sampangine. Interestingly, synthetic analogues of natural pyridoacridine exhibit diverse pharmacological activities and in view of these, natural pyridoacridines can be considered as “lead compounds”. This review additionally provides a brief but critical account of inherent structure activity relationships among various subclasses of pyridoacridines. Furthermore, the current aspects and future prospects of natural pyridoacridines are detailed for further reference and consideration. Elsevier 2015-01 2014-11-15 /pmc/articles/PMC4293674/ /pubmed/25685544 http://dx.doi.org/10.1016/j.jare.2014.11.002 Text en © 2014 Production and hosting by Elsevier B.V. on behalf of Cairo University. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Mini Review
Sharma, Vikas
Sharma, Prabodh C.
Kumar, Vipin
A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry
title A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry
title_full A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry
title_fullStr A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry
title_full_unstemmed A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry
title_short A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry
title_sort mini review on pyridoacridines: prospective lead compounds in medicinal chemistry
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293674/
https://www.ncbi.nlm.nih.gov/pubmed/25685544
http://dx.doi.org/10.1016/j.jare.2014.11.002
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