Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review

Natural products are structurally and biologically interesting metabolites, but they have been isolated in minute amounts. The syntheses of such natural products help in obtaining them in bulk amounts. The recognition of microbial biotransformation as important manufacturing tool has increased in ch...

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Detalles Bibliográficos
Autores principales: Hegazy, Mohamed-Elamir F., Mohamed, Tarik A., ElShamy, Abdelsamed I., Mohamed, Abou-El-Hamd H., Mahalel, Usama A., Reda, Eman H., Shaheen, Alaa M., Tawfik, Wafaa A., Shahat, Abdelaaty A., Shams, Khalid A., Abdel-Azim, Nahla S., Hammouda, Fayza M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293675/
https://www.ncbi.nlm.nih.gov/pubmed/25685541
http://dx.doi.org/10.1016/j.jare.2014.11.009
Descripción
Sumario:Natural products are structurally and biologically interesting metabolites, but they have been isolated in minute amounts. The syntheses of such natural products help in obtaining them in bulk amounts. The recognition of microbial biotransformation as important manufacturing tool has increased in chemical and pharmaceutical industries. In recent years, microbial transformation is increasing significantly from limited interest into highly active area in green chemistry including preparation of pharmaceutical products. This is the first review published on the usage of microbial biocatalysts for some natural product classes and natural product drugs.

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