Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review

Natural products are structurally and biologically interesting metabolites, but they have been isolated in minute amounts. The syntheses of such natural products help in obtaining them in bulk amounts. The recognition of microbial biotransformation as important manufacturing tool has increased in ch...

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Autores principales: Hegazy, Mohamed-Elamir F., Mohamed, Tarik A., ElShamy, Abdelsamed I., Mohamed, Abou-El-Hamd H., Mahalel, Usama A., Reda, Eman H., Shaheen, Alaa M., Tawfik, Wafaa A., Shahat, Abdelaaty A., Shams, Khalid A., Abdel-Azim, Nahla S., Hammouda, Fayza M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293675/
https://www.ncbi.nlm.nih.gov/pubmed/25685541
http://dx.doi.org/10.1016/j.jare.2014.11.009
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author Hegazy, Mohamed-Elamir F.
Mohamed, Tarik A.
ElShamy, Abdelsamed I.
Mohamed, Abou-El-Hamd H.
Mahalel, Usama A.
Reda, Eman H.
Shaheen, Alaa M.
Tawfik, Wafaa A.
Shahat, Abdelaaty A.
Shams, Khalid A.
Abdel-Azim, Nahla S.
Hammouda, Fayza M.
author_facet Hegazy, Mohamed-Elamir F.
Mohamed, Tarik A.
ElShamy, Abdelsamed I.
Mohamed, Abou-El-Hamd H.
Mahalel, Usama A.
Reda, Eman H.
Shaheen, Alaa M.
Tawfik, Wafaa A.
Shahat, Abdelaaty A.
Shams, Khalid A.
Abdel-Azim, Nahla S.
Hammouda, Fayza M.
author_sort Hegazy, Mohamed-Elamir F.
collection PubMed
description Natural products are structurally and biologically interesting metabolites, but they have been isolated in minute amounts. The syntheses of such natural products help in obtaining them in bulk amounts. The recognition of microbial biotransformation as important manufacturing tool has increased in chemical and pharmaceutical industries. In recent years, microbial transformation is increasing significantly from limited interest into highly active area in green chemistry including preparation of pharmaceutical products. This is the first review published on the usage of microbial biocatalysts for some natural product classes and natural product drugs.
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spelling pubmed-42936752015-02-14 Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review Hegazy, Mohamed-Elamir F. Mohamed, Tarik A. ElShamy, Abdelsamed I. Mohamed, Abou-El-Hamd H. Mahalel, Usama A. Reda, Eman H. Shaheen, Alaa M. Tawfik, Wafaa A. Shahat, Abdelaaty A. Shams, Khalid A. Abdel-Azim, Nahla S. Hammouda, Fayza M. J Adv Res Review Natural products are structurally and biologically interesting metabolites, but they have been isolated in minute amounts. The syntheses of such natural products help in obtaining them in bulk amounts. The recognition of microbial biotransformation as important manufacturing tool has increased in chemical and pharmaceutical industries. In recent years, microbial transformation is increasing significantly from limited interest into highly active area in green chemistry including preparation of pharmaceutical products. This is the first review published on the usage of microbial biocatalysts for some natural product classes and natural product drugs. Elsevier 2015-01 2014-11-22 /pmc/articles/PMC4293675/ /pubmed/25685541 http://dx.doi.org/10.1016/j.jare.2014.11.009 Text en © 2014 Production and hosting by Elsevier B.V. on behalf of Cairo University. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Review
Hegazy, Mohamed-Elamir F.
Mohamed, Tarik A.
ElShamy, Abdelsamed I.
Mohamed, Abou-El-Hamd H.
Mahalel, Usama A.
Reda, Eman H.
Shaheen, Alaa M.
Tawfik, Wafaa A.
Shahat, Abdelaaty A.
Shams, Khalid A.
Abdel-Azim, Nahla S.
Hammouda, Fayza M.
Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review
title Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review
title_full Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review
title_fullStr Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review
title_full_unstemmed Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review
title_short Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review
title_sort microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293675/
https://www.ncbi.nlm.nih.gov/pubmed/25685541
http://dx.doi.org/10.1016/j.jare.2014.11.009
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