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Immunomodulatory Effects of Triphala and its Individual Constituents: A Review

The role of plant extracts and Ayurvedic polyherbal preparations in treating various ailments has been acknowledged since time immemorial. Studies based on the effect of these extracts in treatment of different diseases have also been well documented. Indian medicinal literature also emphasizes the...

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Autores principales: Belapurkar, Pranoti, Goyal, Pragya, Tiwari-Barua, Preeti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293677/
https://www.ncbi.nlm.nih.gov/pubmed/25593379
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author Belapurkar, Pranoti
Goyal, Pragya
Tiwari-Barua, Preeti
author_facet Belapurkar, Pranoti
Goyal, Pragya
Tiwari-Barua, Preeti
author_sort Belapurkar, Pranoti
collection PubMed
description The role of plant extracts and Ayurvedic polyherbal preparations in treating various ailments has been acknowledged since time immemorial. Studies based on the effect of these extracts in treatment of different diseases have also been well documented. Indian medicinal literature also emphasizes the synergistic effect of polyherbal drugs in restoring and rejuvenating immune system. This review focuses on the immunomodulatory potential of the polyherbal preparation, Triphala and its three constituents, Terminalia bellerica, Terminalia chebula and Emblica officinalis. The role of Triphala and its extract has been emphasized in stimulating neutrophil function. Under stress condition such as noise, Triphala significantly prevents elevation of IL-4 levels as well as corrects decreased IL-2 and IFN-γ levels. Under the condition of inflammatory stress its immunosuppressive activity is attributed to its inhibitory action on complement system, humoral immunity, cell mediated immunity and mitogen-induced T-lymphocyte proliferation. The aqueous and alcoholic extracts of the individual constituents reportedly enhance especially the macrophage activation due to their free radical scavenging activity and the ability to neutralize reactive oxygen species. This study thus concludes the use of Triphala and its three individual constituents as potential immunostimulants and/or immunosuppressants further suggests them to be a better alternative for allopathic immunomodulators.
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spelling pubmed-42936772015-01-15 Immunomodulatory Effects of Triphala and its Individual Constituents: A Review Belapurkar, Pranoti Goyal, Pragya Tiwari-Barua, Preeti Indian J Pharm Sci Review Article The role of plant extracts and Ayurvedic polyherbal preparations in treating various ailments has been acknowledged since time immemorial. Studies based on the effect of these extracts in treatment of different diseases have also been well documented. Indian medicinal literature also emphasizes the synergistic effect of polyherbal drugs in restoring and rejuvenating immune system. This review focuses on the immunomodulatory potential of the polyherbal preparation, Triphala and its three constituents, Terminalia bellerica, Terminalia chebula and Emblica officinalis. The role of Triphala and its extract has been emphasized in stimulating neutrophil function. Under stress condition such as noise, Triphala significantly prevents elevation of IL-4 levels as well as corrects decreased IL-2 and IFN-γ levels. Under the condition of inflammatory stress its immunosuppressive activity is attributed to its inhibitory action on complement system, humoral immunity, cell mediated immunity and mitogen-induced T-lymphocyte proliferation. The aqueous and alcoholic extracts of the individual constituents reportedly enhance especially the macrophage activation due to their free radical scavenging activity and the ability to neutralize reactive oxygen species. This study thus concludes the use of Triphala and its three individual constituents as potential immunostimulants and/or immunosuppressants further suggests them to be a better alternative for allopathic immunomodulators. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4293677/ /pubmed/25593379 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Belapurkar, Pranoti
Goyal, Pragya
Tiwari-Barua, Preeti
Immunomodulatory Effects of Triphala and its Individual Constituents: A Review
title Immunomodulatory Effects of Triphala and its Individual Constituents: A Review
title_full Immunomodulatory Effects of Triphala and its Individual Constituents: A Review
title_fullStr Immunomodulatory Effects of Triphala and its Individual Constituents: A Review
title_full_unstemmed Immunomodulatory Effects of Triphala and its Individual Constituents: A Review
title_short Immunomodulatory Effects of Triphala and its Individual Constituents: A Review
title_sort immunomodulatory effects of triphala and its individual constituents: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293677/
https://www.ncbi.nlm.nih.gov/pubmed/25593379
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