A Facile Synthesis, In vitro Antiinflammatory and Antioxidant activity of Novel Benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitriles

The synthesis benzimidazolylpyrano [2,3-d] [1,3] thiazolocarbonitriles (5a-j) were achieved by cyclocondensation of arylidene amino-benzo[d]imidazole-2-thiols (3a-j) with mercaptoacetic acid followed by cyclization with 2-(phenylmethylene)malononitrile. Further more, the present study aimed at the e...

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Detalles Bibliográficos
Autores principales: Malladi, S. R., Anisetti, R., Rao, P. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293682/
https://www.ncbi.nlm.nih.gov/pubmed/25593384
Descripción
Sumario:The synthesis benzimidazolylpyrano [2,3-d] [1,3] thiazolocarbonitriles (5a-j) were achieved by cyclocondensation of arylidene amino-benzo[d]imidazole-2-thiols (3a-j) with mercaptoacetic acid followed by cyclization with 2-(phenylmethylene)malononitrile. Further more, the present study aimed at the evaluation of in vitro antiinflammatory activity and antioxidant activity of synthetic compounds. All tested compounds showed appreciable activity against the standard drugs.

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