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Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data

OBJECTIVES: We aimed to review the literature linking metabolic factors to Diffuse Idiopathic Skeletal Hyperostosis (DISH), in order to assess associations between growth factors and DISH. METHOD: We identified studies in our personal database and PubMed using the following keywords in various combi...

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Autores principales: Pillai, Sruti, Littlejohn, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293739/
https://www.ncbi.nlm.nih.gov/pubmed/25598855
http://dx.doi.org/10.2174/1874312901408010116
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author Pillai, Sruti
Littlejohn, Geoffrey
author_facet Pillai, Sruti
Littlejohn, Geoffrey
author_sort Pillai, Sruti
collection PubMed
description OBJECTIVES: We aimed to review the literature linking metabolic factors to Diffuse Idiopathic Skeletal Hyperostosis (DISH), in order to assess associations between growth factors and DISH. METHOD: We identified studies in our personal database and PubMed using the following keywords in various combinations: “diffuse idiopathic skeletal hyperostosis”, “ankylosing hyperostosis”, “Forestier’s disease”, “diabetes”, “insulin”, “obesity”, “metabolic”, “growth factors”, “adipokines”, “glucose tolerance” and “chondrocytes”. RESULTS: We were not able to do a systematic review due to variability in methodology of studies. We found positive associations between obesity (especially abdominal obesity), Type 2 diabetes mellitus, glucose intolerance, hyperinsulinemia and DISH. CONCLUSION: Current research indicates that certain metabolic factors associate with DISH. More precise studies deriving from these findings on these and other newly identified bone-growth factors are needed.
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spelling pubmed-42937392015-01-16 Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data Pillai, Sruti Littlejohn, Geoffrey Open Rheumatol J Article OBJECTIVES: We aimed to review the literature linking metabolic factors to Diffuse Idiopathic Skeletal Hyperostosis (DISH), in order to assess associations between growth factors and DISH. METHOD: We identified studies in our personal database and PubMed using the following keywords in various combinations: “diffuse idiopathic skeletal hyperostosis”, “ankylosing hyperostosis”, “Forestier’s disease”, “diabetes”, “insulin”, “obesity”, “metabolic”, “growth factors”, “adipokines”, “glucose tolerance” and “chondrocytes”. RESULTS: We were not able to do a systematic review due to variability in methodology of studies. We found positive associations between obesity (especially abdominal obesity), Type 2 diabetes mellitus, glucose intolerance, hyperinsulinemia and DISH. CONCLUSION: Current research indicates that certain metabolic factors associate with DISH. More precise studies deriving from these findings on these and other newly identified bone-growth factors are needed. Bentham Open 2014-12-19 /pmc/articles/PMC4293739/ /pubmed/25598855 http://dx.doi.org/10.2174/1874312901408010116 Text en © Pillai and Littlejohn; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Pillai, Sruti
Littlejohn, Geoffrey
Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data
title Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data
title_full Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data
title_fullStr Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data
title_full_unstemmed Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data
title_short Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data
title_sort metabolic factors in diffuse idiopathic skeletal hyperostosis – a review of clinical data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293739/
https://www.ncbi.nlm.nih.gov/pubmed/25598855
http://dx.doi.org/10.2174/1874312901408010116
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