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Gastroprotective effect of aqueous extract and mucilage from Bryophyllum pinnatum (Lam.) Kurz

CONTEXT: Bryophyllum pinnatum is used as traditional medicine in India, Africa, Tropical America and China for treatment of various diseases. B. pinnatum contains different groups of phytoconstituents viz., flavonoid, terpenoids, alkaloid, phenolic compounds. AIM: The present study was carried out t...

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Autores principales: Sharma, Abhishek L., Bhot, Meeta A., Chandra, Naresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293753/
https://www.ncbi.nlm.nih.gov/pubmed/25593406
http://dx.doi.org/10.4103/0257-7941.147434
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author Sharma, Abhishek L.
Bhot, Meeta A.
Chandra, Naresh
author_facet Sharma, Abhishek L.
Bhot, Meeta A.
Chandra, Naresh
author_sort Sharma, Abhishek L.
collection PubMed
description CONTEXT: Bryophyllum pinnatum is used as traditional medicine in India, Africa, Tropical America and China for treatment of various diseases. B. pinnatum contains different groups of phytoconstituents viz., flavonoid, terpenoids, alkaloid, phenolic compounds. AIM: The present study was carried out to evaluate the gastroprotective activity of B. pinnatum whole plant aqueous extract, and mucilage (MUC) isolated from the whole plant against ethanol induced gastric ulcer. MATERIALS AND METHODS: Pretreatment of rats with aqueous extract at dose level of 500 and 750 mg/kg b.w., MUC at 500 mg/kg dose level and standard drug Rabeprazole at dose level of 20 mg/kg b.w. where given for 7 days. RESULTS: The aqueous whole plant extract of B. pinnatum at dose of 750 mg/kg p.o. and MUC at dose of 500 mg/kg p.o. markedly decrease the incidence of ulcers in ethanol induced ulcer rats. In ethanol induced ulcer rats, there was a decrease in the gastric volume, free and total acidity and ulcerative index as compared to the control group. Total carbohydrate content was found to be an increase as compare to control the group. The aqueous whole plant extract of B. pinnatum at dose of 750 mg/kg showed a significant reduction in the above parameters which was comparable to the standard drug rabeprazole (20 mg/kg). B. pinnatum extract and MUC showed protection index 72.69 and 69.65% respectively, whereas standard drug rabeprazole showed protection index 75.49%. CONCLUSIONS: Whole plant extracts of B. pinnatum and MUC has potent gastroprotective effect which can be further clinically studied for new drug development.
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spelling pubmed-42937532015-01-15 Gastroprotective effect of aqueous extract and mucilage from Bryophyllum pinnatum (Lam.) Kurz Sharma, Abhishek L. Bhot, Meeta A. Chandra, Naresh Anc Sci Life Original Article CONTEXT: Bryophyllum pinnatum is used as traditional medicine in India, Africa, Tropical America and China for treatment of various diseases. B. pinnatum contains different groups of phytoconstituents viz., flavonoid, terpenoids, alkaloid, phenolic compounds. AIM: The present study was carried out to evaluate the gastroprotective activity of B. pinnatum whole plant aqueous extract, and mucilage (MUC) isolated from the whole plant against ethanol induced gastric ulcer. MATERIALS AND METHODS: Pretreatment of rats with aqueous extract at dose level of 500 and 750 mg/kg b.w., MUC at 500 mg/kg dose level and standard drug Rabeprazole at dose level of 20 mg/kg b.w. where given for 7 days. RESULTS: The aqueous whole plant extract of B. pinnatum at dose of 750 mg/kg p.o. and MUC at dose of 500 mg/kg p.o. markedly decrease the incidence of ulcers in ethanol induced ulcer rats. In ethanol induced ulcer rats, there was a decrease in the gastric volume, free and total acidity and ulcerative index as compared to the control group. Total carbohydrate content was found to be an increase as compare to control the group. The aqueous whole plant extract of B. pinnatum at dose of 750 mg/kg showed a significant reduction in the above parameters which was comparable to the standard drug rabeprazole (20 mg/kg). B. pinnatum extract and MUC showed protection index 72.69 and 69.65% respectively, whereas standard drug rabeprazole showed protection index 75.49%. CONCLUSIONS: Whole plant extracts of B. pinnatum and MUC has potent gastroprotective effect which can be further clinically studied for new drug development. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4293753/ /pubmed/25593406 http://dx.doi.org/10.4103/0257-7941.147434 Text en Copyright: © Ancient Science of Life http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sharma, Abhishek L.
Bhot, Meeta A.
Chandra, Naresh
Gastroprotective effect of aqueous extract and mucilage from Bryophyllum pinnatum (Lam.) Kurz
title Gastroprotective effect of aqueous extract and mucilage from Bryophyllum pinnatum (Lam.) Kurz
title_full Gastroprotective effect of aqueous extract and mucilage from Bryophyllum pinnatum (Lam.) Kurz
title_fullStr Gastroprotective effect of aqueous extract and mucilage from Bryophyllum pinnatum (Lam.) Kurz
title_full_unstemmed Gastroprotective effect of aqueous extract and mucilage from Bryophyllum pinnatum (Lam.) Kurz
title_short Gastroprotective effect of aqueous extract and mucilage from Bryophyllum pinnatum (Lam.) Kurz
title_sort gastroprotective effect of aqueous extract and mucilage from bryophyllum pinnatum (lam.) kurz
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293753/
https://www.ncbi.nlm.nih.gov/pubmed/25593406
http://dx.doi.org/10.4103/0257-7941.147434
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