#Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1

Influenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with the in vitro antiviral tests. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Saad, Dalya, Memeo, Misal Giuseppe, Quadrelli, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293787/
https://www.ncbi.nlm.nih.gov/pubmed/25610906
http://dx.doi.org/10.1155/2014/472373
_version_ 1782352644598136832
author Al-Saad, Dalya
Memeo, Misal Giuseppe
Quadrelli, Paolo
author_facet Al-Saad, Dalya
Memeo, Misal Giuseppe
Quadrelli, Paolo
author_sort Al-Saad, Dalya
collection PubMed
description Influenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with the in vitro antiviral tests. The nucleoside derivatives were tested for their inhibitory activity against a variety of viruses. Promising antiviral activities were found for specific compounds in the case of flu A H1N1.
format Online
Article
Text
id pubmed-4293787
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-42937872015-01-21 #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1 Al-Saad, Dalya Memeo, Misal Giuseppe Quadrelli, Paolo ScientificWorldJournal Research Article Influenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with the in vitro antiviral tests. The nucleoside derivatives were tested for their inhibitory activity against a variety of viruses. Promising antiviral activities were found for specific compounds in the case of flu A H1N1. Hindawi Publishing Corporation 2014 2014-12-31 /pmc/articles/PMC4293787/ /pubmed/25610906 http://dx.doi.org/10.1155/2014/472373 Text en Copyright © 2014 Dalya Al-Saad et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Al-Saad, Dalya
Memeo, Misal Giuseppe
Quadrelli, Paolo
#Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1
title #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1
title_full #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1
title_fullStr #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1
title_full_unstemmed #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1
title_short #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1
title_sort #nitrosocarbonyls 1: antiviral activity of n-(4-hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the influenza a virus h1n1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293787/
https://www.ncbi.nlm.nih.gov/pubmed/25610906
http://dx.doi.org/10.1155/2014/472373
work_keys_str_mv AT alsaaddalya nitrosocarbonyls1antiviralactivityofn4hydroxycyclohex2en1ylquinoline2carboxamideagainsttheinfluenzaavirush1n1
AT memeomisalgiuseppe nitrosocarbonyls1antiviralactivityofn4hydroxycyclohex2en1ylquinoline2carboxamideagainsttheinfluenzaavirush1n1
AT quadrellipaolo nitrosocarbonyls1antiviralactivityofn4hydroxycyclohex2en1ylquinoline2carboxamideagainsttheinfluenzaavirush1n1

Ejemplares similares