Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP

Successful clearance of hepatitis B virus (HBV) is a promising event in which host’s immune system will attempt to get rid of the virus. The immunological events of HBsAg seroclearance have attracted great attention in both natural history investigations and therapeutic trials. Recent genome-wide as...

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Autores principales: Mohamadkhani, Ashraf, Katoonizadeh, Aezam, Poustchi, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293802/
https://www.ncbi.nlm.nih.gov/pubmed/25628847
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author Mohamadkhani, Ashraf
Katoonizadeh, Aezam
Poustchi, Hossein
author_facet Mohamadkhani, Ashraf
Katoonizadeh, Aezam
Poustchi, Hossein
author_sort Mohamadkhani, Ashraf
collection PubMed
description Successful clearance of hepatitis B virus (HBV) is a promising event in which host’s immune system will attempt to get rid of the virus. The immunological events of HBsAg seroclearance have attracted great attention in both natural history investigations and therapeutic trials. Recent genome-wide association studies (GWAS) has confirmed polymorphisms in the human leukocyte antigen (HLA)-DP locus associated with spontaneous HBV clearance. In this review the impact of host immune response in declining HBsAg during the natural history of the infection has been discussed.
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spelling pubmed-42938022015-01-27 Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP Mohamadkhani, Ashraf Katoonizadeh, Aezam Poustchi, Hossein Middle East J Dig Dis Review Article Successful clearance of hepatitis B virus (HBV) is a promising event in which host’s immune system will attempt to get rid of the virus. The immunological events of HBsAg seroclearance have attracted great attention in both natural history investigations and therapeutic trials. Recent genome-wide association studies (GWAS) has confirmed polymorphisms in the human leukocyte antigen (HLA)-DP locus associated with spontaneous HBV clearance. In this review the impact of host immune response in declining HBsAg during the natural history of the infection has been discussed. Iranian Association of Gastroerterology and Hepatology 2015-01 /pmc/articles/PMC4293802/ /pubmed/25628847 Text en © 2015 by Middle East Journal of Digestive Diseases This work is published by Middle East Journal of Digestive Diseases as an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-sa/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Review Article
Mohamadkhani, Ashraf
Katoonizadeh, Aezam
Poustchi, Hossein
Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP
title Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP
title_full Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP
title_fullStr Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP
title_full_unstemmed Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP
title_short Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP
title_sort immune-regulatory events in the clearance of hbsag in chronic hepatitis b: focuses on hla-dp
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293802/
https://www.ncbi.nlm.nih.gov/pubmed/25628847
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