Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents

Long before synaptic loss occurs in Alzheimer’s disease significant harbingers of disease may be detected at the functional level. Here we examined if synaptic long-term potentiation is selectively disrupted prior to extracellular deposition of Aß in a very complete model of Alzheimer’s disease amyl...

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Detalles Bibliográficos
Autores principales: Qi, Yingjie, Klyubin, Igor, Harney, Sarah C, Hu, NengWei, Cullen, William K, Grant, Marianne K, Steffen, Julia, Wilson, Edward N, Do Carmo, Sonia, Remy, Stefan, Fuhrmann, Martin, Ashe, Karen H, Cuello, A Claudio, Rowan, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293804/
https://www.ncbi.nlm.nih.gov/pubmed/25540024
http://dx.doi.org/10.1186/s40478-014-0175-x

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