The role of microglia and myeloid immune cells in acute cerebral ischemia

The immune response to acute cerebral ischemia is a major contributor to stroke pathobiology. The inflammatory response is characterized by the participation of brain resident cells and peripheral leukocytes. Microglia in the brain and monocytes/neutrophils in the periphery have a prominent role in...

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Autores principales: Benakis, Corinne, Garcia-Bonilla, Lidia, Iadecola, Costantino, Anrather, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294142/
https://www.ncbi.nlm.nih.gov/pubmed/25642168
http://dx.doi.org/10.3389/fncel.2014.00461
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author Benakis, Corinne
Garcia-Bonilla, Lidia
Iadecola, Costantino
Anrather, Josef
author_facet Benakis, Corinne
Garcia-Bonilla, Lidia
Iadecola, Costantino
Anrather, Josef
author_sort Benakis, Corinne
collection PubMed
description The immune response to acute cerebral ischemia is a major contributor to stroke pathobiology. The inflammatory response is characterized by the participation of brain resident cells and peripheral leukocytes. Microglia in the brain and monocytes/neutrophils in the periphery have a prominent role in initiating, sustaining and resolving post-ischemic inflammation. In this review we aim to summarize recent literature concerning the origins, fate and role of microglia, monocytes and neutrophils in models of cerebral ischemia and to discuss their relevance for human stroke.
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spelling pubmed-42941422015-01-30 The role of microglia and myeloid immune cells in acute cerebral ischemia Benakis, Corinne Garcia-Bonilla, Lidia Iadecola, Costantino Anrather, Josef Front Cell Neurosci Neuroscience The immune response to acute cerebral ischemia is a major contributor to stroke pathobiology. The inflammatory response is characterized by the participation of brain resident cells and peripheral leukocytes. Microglia in the brain and monocytes/neutrophils in the periphery have a prominent role in initiating, sustaining and resolving post-ischemic inflammation. In this review we aim to summarize recent literature concerning the origins, fate and role of microglia, monocytes and neutrophils in models of cerebral ischemia and to discuss their relevance for human stroke. Frontiers Media S.A. 2015-01-14 /pmc/articles/PMC4294142/ /pubmed/25642168 http://dx.doi.org/10.3389/fncel.2014.00461 Text en Copyright © 2015 Benakis, Garcia-Bonilla, Iadecola and Anrather. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Benakis, Corinne
Garcia-Bonilla, Lidia
Iadecola, Costantino
Anrather, Josef
The role of microglia and myeloid immune cells in acute cerebral ischemia
title The role of microglia and myeloid immune cells in acute cerebral ischemia
title_full The role of microglia and myeloid immune cells in acute cerebral ischemia
title_fullStr The role of microglia and myeloid immune cells in acute cerebral ischemia
title_full_unstemmed The role of microglia and myeloid immune cells in acute cerebral ischemia
title_short The role of microglia and myeloid immune cells in acute cerebral ischemia
title_sort role of microglia and myeloid immune cells in acute cerebral ischemia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294142/
https://www.ncbi.nlm.nih.gov/pubmed/25642168
http://dx.doi.org/10.3389/fncel.2014.00461
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