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Effect of transcatheter aortic valve implantation on QT dispersion in patients with aortic stenosis

BACKGROUND: QT dispersion (QTd) is a predictor of ventricular arrhythmia. Ventricular arrhythmia is an important factor influencing morbidity and mortality in patients with aortic stenosis. Surgical aortic valve replacement reduced the QTd in this patients group. However, the effect of transcatheter...

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Autores principales: Erkan, Hakan, Hatem, Engin, Ağaç, Mustafa Tarık, Korkmaz, Levent, Gökdeniz, Teyyar, Aykan, Ahmet Çağrı, Kalaycıoğlu, Ezgi, Boyacı, Faruk, Çırakoğlu, Ömer Faruk, Çelik, Şükrü
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294144/
https://www.ncbi.nlm.nih.gov/pubmed/25593576
http://dx.doi.org/10.11909/j.issn.1671-5411.2014.04.002
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author Erkan, Hakan
Hatem, Engin
Ağaç, Mustafa Tarık
Korkmaz, Levent
Gökdeniz, Teyyar
Aykan, Ahmet Çağrı
Kalaycıoğlu, Ezgi
Boyacı, Faruk
Çırakoğlu, Ömer Faruk
Çelik, Şükrü
author_facet Erkan, Hakan
Hatem, Engin
Ağaç, Mustafa Tarık
Korkmaz, Levent
Gökdeniz, Teyyar
Aykan, Ahmet Çağrı
Kalaycıoğlu, Ezgi
Boyacı, Faruk
Çırakoğlu, Ömer Faruk
Çelik, Şükrü
author_sort Erkan, Hakan
collection PubMed
description BACKGROUND: QT dispersion (QTd) is a predictor of ventricular arrhythmia. Ventricular arrhythmia is an important factor influencing morbidity and mortality in patients with aortic stenosis. Surgical aortic valve replacement reduced the QTd in this patients group. However, the effect of transcatheter aortic valve implantation (TAVI) on QTd in patients with aortic stenosis is unknown. The aim of this study was to investigate the effect of TAVI on QTd in patients with aortic stenosis. METHODS: Patients with severe aortic stenosis, who were not candidates for surgical aortic valve replacement due to contraindications or high surgical risk, were included in the study. All patients underwent electrocardiographic and echocardiographic evaluation before, and at the 6(th) month after TAVI, computed QTd and left ventricular mass index (LVMI). RESULTS: A total 30 patients were admitted to the study (mean age 83.2 ± 1.0 years, female 21 and male 9, mean valve area 0.7 ± 3 mm(2)). Edwards SAPIEN heart valves, 23 mm (21 patients) and 26 mm (9 patients), by the transfemoral approach were used in the TAVI procedures. All TAVI procedures were successful. Both QTd and LVMI at the 6(th) month after TAVI were significantly reduced compared with baseline values of QTd and LVMI before TAVI (73.8 ± 4 ms vs. 68 ± 2 ms, P = 0.001 and 198 ± 51 g/m(2) vs. 184 ± 40 g/m(2), P = 0.04, respectively). There was a significant correlation between QTd and LVMI (r = 0.646, P < 0.001). CONCLUSIONS: QTd, which malign ventricular arrhythmia marker, and LVMI were significantly reduced after TAVI procedure. TAVI may decrease the possibility of ventricular arrhythmia in patients with aortic stenosis.
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spelling pubmed-42941442015-01-20 Effect of transcatheter aortic valve implantation on QT dispersion in patients with aortic stenosis Erkan, Hakan Hatem, Engin Ağaç, Mustafa Tarık Korkmaz, Levent Gökdeniz, Teyyar Aykan, Ahmet Çağrı Kalaycıoğlu, Ezgi Boyacı, Faruk Çırakoğlu, Ömer Faruk Çelik, Şükrü J Geriatr Cardiol Research Article BACKGROUND: QT dispersion (QTd) is a predictor of ventricular arrhythmia. Ventricular arrhythmia is an important factor influencing morbidity and mortality in patients with aortic stenosis. Surgical aortic valve replacement reduced the QTd in this patients group. However, the effect of transcatheter aortic valve implantation (TAVI) on QTd in patients with aortic stenosis is unknown. The aim of this study was to investigate the effect of TAVI on QTd in patients with aortic stenosis. METHODS: Patients with severe aortic stenosis, who were not candidates for surgical aortic valve replacement due to contraindications or high surgical risk, were included in the study. All patients underwent electrocardiographic and echocardiographic evaluation before, and at the 6(th) month after TAVI, computed QTd and left ventricular mass index (LVMI). RESULTS: A total 30 patients were admitted to the study (mean age 83.2 ± 1.0 years, female 21 and male 9, mean valve area 0.7 ± 3 mm(2)). Edwards SAPIEN heart valves, 23 mm (21 patients) and 26 mm (9 patients), by the transfemoral approach were used in the TAVI procedures. All TAVI procedures were successful. Both QTd and LVMI at the 6(th) month after TAVI were significantly reduced compared with baseline values of QTd and LVMI before TAVI (73.8 ± 4 ms vs. 68 ± 2 ms, P = 0.001 and 198 ± 51 g/m(2) vs. 184 ± 40 g/m(2), P = 0.04, respectively). There was a significant correlation between QTd and LVMI (r = 0.646, P < 0.001). CONCLUSIONS: QTd, which malign ventricular arrhythmia marker, and LVMI were significantly reduced after TAVI procedure. TAVI may decrease the possibility of ventricular arrhythmia in patients with aortic stenosis. Science Press 2014-12 /pmc/articles/PMC4294144/ /pubmed/25593576 http://dx.doi.org/10.11909/j.issn.1671-5411.2014.04.002 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Research Article
Erkan, Hakan
Hatem, Engin
Ağaç, Mustafa Tarık
Korkmaz, Levent
Gökdeniz, Teyyar
Aykan, Ahmet Çağrı
Kalaycıoğlu, Ezgi
Boyacı, Faruk
Çırakoğlu, Ömer Faruk
Çelik, Şükrü
Effect of transcatheter aortic valve implantation on QT dispersion in patients with aortic stenosis
title Effect of transcatheter aortic valve implantation on QT dispersion in patients with aortic stenosis
title_full Effect of transcatheter aortic valve implantation on QT dispersion in patients with aortic stenosis
title_fullStr Effect of transcatheter aortic valve implantation on QT dispersion in patients with aortic stenosis
title_full_unstemmed Effect of transcatheter aortic valve implantation on QT dispersion in patients with aortic stenosis
title_short Effect of transcatheter aortic valve implantation on QT dispersion in patients with aortic stenosis
title_sort effect of transcatheter aortic valve implantation on qt dispersion in patients with aortic stenosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294144/
https://www.ncbi.nlm.nih.gov/pubmed/25593576
http://dx.doi.org/10.11909/j.issn.1671-5411.2014.04.002
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