Cargando…
The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer’s disease phenotype
Alzheimer’s disease (AD) is the most common, and, arguably, one of the most-well studied, neurodegenerative conditions. Several decades of investigation have revealed that amyloid-β and tau proteins are critical pathological players in this condition. Genetic analyses have revealed specific mutation...
Autores principales: | Joshi, Yash B., Praticò, Domenico |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294160/ https://www.ncbi.nlm.nih.gov/pubmed/25642165 http://dx.doi.org/10.3389/fncel.2014.00436 |
Ejemplares similares
-
Knockout of 5-Lipoxygenase Results in Age-Dependent Anxiety-Like Behavior in Female Mice
por: Joshi, Yash B., et al.
Publicado: (2011) -
Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
por: Chu, Jin, et al.
Publicado: (2012) -
Gene Knockout of 5-Lipoxygenase Rescues Synaptic Dysfunction and Improves Memory in the Triple-Transgenic Model of Alzheimer’s Disease
por: Giannopoulos, Phillip F., et al.
Publicado: (2013) -
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer’s phenotype
por: Li, Jian-Guo, et al.
Publicado: (2017) -
Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer’s Disease Pathology
por: Di Meco, Antonio, et al.
Publicado: (2018)