The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic

The ABT-analogous 737, 263 and 199 are BH3 mimetics showing potent anti-myeloma (MM) activity, but only on defined molecular subgroups of MM patients presenting a Bcl-2(high)/Mcl-1(low) profile. IGF-1 is a major survival factor in MM regulating the expression of Bcl-2 proteins and might therefore be...

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Detalles Bibliográficos
Autores principales: Bieghs, Liesbeth, Lub, Susanne, Fostier, Karel, Maes, Ken, Van Valckenborgh, Els, Menu, Eline, Johnsen, Hans E., Overgaard, Michael T., Larsson, Olle, Axelson, Magnus, Nyegaard, Mette, Schots, Rik, Jernberg-Wiklund, Helena, Vanderkerken, Karin, De Bruyne, Elke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294345/
https://www.ncbi.nlm.nih.gov/pubmed/25008202

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