MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors

Our previous study demonstrated NVP-AUY922, a HSP90AA1 inhibitor, could enhance mutant KIT degradation in gastrointestinal stromal tumor (GIST) cells through both proteasome- and autophagy-mediated pathways. Herein, we showed rapamycin, a MTOR inhibitor and autophagy inducer, could reduce total and...

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Detalles Bibliográficos
Autores principales: Hsueh, Yuan-Shuo, Chang, Hui Hua, Chiang, Nai-Jung, Yen, Chueh-Chuan, Li, Chien-Feng, Chen, Li-Tzong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294368/
https://www.ncbi.nlm.nih.gov/pubmed/25375091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294368/
https://www.ncbi.nlm.nih.gov/pubmed/25375091

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