Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

Epidemiological and preclinical studies propose that metformin, a first-line drug for type-2 diabetes, exerts direct antitumor activity. Although several clinical trials are ongoing, the molecular mechanisms of this effect are unknown. Here we show that chloride intracellular channel-1 (CLIC1) is a...

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Detalles Bibliográficos
Autores principales: Gritti, Marta, Würth, Roberto, Angelini, Marina, Barbieri, Federica, Peretti, Marta, Pizzi, Erika, Pattarozzi, Alessandra, Carra, Elisa, Sirito, Rodolfo, Daga, Antonio, Curmi, Paul M.G., Mazzanti, Michele, Florio, Tullio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294381/
https://www.ncbi.nlm.nih.gov/pubmed/25361004

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