Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP

Recent evidence showed that a variety of DNA damaging agents including 5-FU and L-OHP impairs ribosomal biogenesis activating a ribosomal stress pathway. Here, we demonstrate that in lung and colon cancer cell lines devoid of p53, the efficacy of 5-FU and L-OHP chemotherapy depends on rpL3 status. S...

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Detalles Bibliográficos
Autores principales: Esposito, Davide, Crescenzi, Elvira, Sagar, Vinay, Loreni, Fabrizio, Russo, Annapina, Russo, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294388/
https://www.ncbi.nlm.nih.gov/pubmed/25473889

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