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Mastl kinase, a promising therapeutic target, promotes cancer recurrence

Mastl kinase promotes mitotic progression and cell cycle reentry after DNA damage. We report here that Mastl is frequently upregulated in various types of cancer. This upregulation was correlated with cancer progression in breast and oral cancer, poor patient survival in breast cancer, and tumor rec...

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Detalles Bibliográficos
Autores principales: Wang, Ling, Luong, Vivian Q., Giannini, Peter J., Peng, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294390/
https://www.ncbi.nlm.nih.gov/pubmed/25373736
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author Wang, Ling
Luong, Vivian Q.
Giannini, Peter J.
Peng, Aimin
author_facet Wang, Ling
Luong, Vivian Q.
Giannini, Peter J.
Peng, Aimin
author_sort Wang, Ling
collection PubMed
description Mastl kinase promotes mitotic progression and cell cycle reentry after DNA damage. We report here that Mastl is frequently upregulated in various types of cancer. This upregulation was correlated with cancer progression in breast and oral cancer, poor patient survival in breast cancer, and tumor recurrence in head and neck squamous cell carcinoma. We further investigated the role of Mastl in tumor resistance using cell lines derived from the initial and recurrent tumors of the same head and neck squamous cell carcinoma patients. Ectopic expression of Mastl in the initial tumor cells strongly promoted cell proliferation in the presence of cisplatin by attenuating DNA damage signaling and cell death. Mastl knockdown in recurrent tumor cells re-sensitized their response to cancer therapy in vitro and in vivo. Finally, Mastl targeting specifically potentiated cancer cells to cell death in chemotherapy while sparing normal cells. Thus, this study revealed that Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy, and validated Mastl as a promising target to increase the therapeutic window.
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spelling pubmed-42943902015-01-21 Mastl kinase, a promising therapeutic target, promotes cancer recurrence Wang, Ling Luong, Vivian Q. Giannini, Peter J. Peng, Aimin Oncotarget Research Paper Mastl kinase promotes mitotic progression and cell cycle reentry after DNA damage. We report here that Mastl is frequently upregulated in various types of cancer. This upregulation was correlated with cancer progression in breast and oral cancer, poor patient survival in breast cancer, and tumor recurrence in head and neck squamous cell carcinoma. We further investigated the role of Mastl in tumor resistance using cell lines derived from the initial and recurrent tumors of the same head and neck squamous cell carcinoma patients. Ectopic expression of Mastl in the initial tumor cells strongly promoted cell proliferation in the presence of cisplatin by attenuating DNA damage signaling and cell death. Mastl knockdown in recurrent tumor cells re-sensitized their response to cancer therapy in vitro and in vivo. Finally, Mastl targeting specifically potentiated cancer cells to cell death in chemotherapy while sparing normal cells. Thus, this study revealed that Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy, and validated Mastl as a promising target to increase the therapeutic window. Impact Journals LLC 2014-12-22 /pmc/articles/PMC4294390/ /pubmed/25373736 Text en Copyright: © 2014 Wang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Paper
Wang, Ling
Luong, Vivian Q.
Giannini, Peter J.
Peng, Aimin
Mastl kinase, a promising therapeutic target, promotes cancer recurrence
title Mastl kinase, a promising therapeutic target, promotes cancer recurrence
title_full Mastl kinase, a promising therapeutic target, promotes cancer recurrence
title_fullStr Mastl kinase, a promising therapeutic target, promotes cancer recurrence
title_full_unstemmed Mastl kinase, a promising therapeutic target, promotes cancer recurrence
title_short Mastl kinase, a promising therapeutic target, promotes cancer recurrence
title_sort mastl kinase, a promising therapeutic target, promotes cancer recurrence
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294390/
https://www.ncbi.nlm.nih.gov/pubmed/25373736
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