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Mastl kinase, a promising therapeutic target, promotes cancer recurrence
Mastl kinase promotes mitotic progression and cell cycle reentry after DNA damage. We report here that Mastl is frequently upregulated in various types of cancer. This upregulation was correlated with cancer progression in breast and oral cancer, poor patient survival in breast cancer, and tumor rec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294390/ https://www.ncbi.nlm.nih.gov/pubmed/25373736 |
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author | Wang, Ling Luong, Vivian Q. Giannini, Peter J. Peng, Aimin |
author_facet | Wang, Ling Luong, Vivian Q. Giannini, Peter J. Peng, Aimin |
author_sort | Wang, Ling |
collection | PubMed |
description | Mastl kinase promotes mitotic progression and cell cycle reentry after DNA damage. We report here that Mastl is frequently upregulated in various types of cancer. This upregulation was correlated with cancer progression in breast and oral cancer, poor patient survival in breast cancer, and tumor recurrence in head and neck squamous cell carcinoma. We further investigated the role of Mastl in tumor resistance using cell lines derived from the initial and recurrent tumors of the same head and neck squamous cell carcinoma patients. Ectopic expression of Mastl in the initial tumor cells strongly promoted cell proliferation in the presence of cisplatin by attenuating DNA damage signaling and cell death. Mastl knockdown in recurrent tumor cells re-sensitized their response to cancer therapy in vitro and in vivo. Finally, Mastl targeting specifically potentiated cancer cells to cell death in chemotherapy while sparing normal cells. Thus, this study revealed that Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy, and validated Mastl as a promising target to increase the therapeutic window. |
format | Online Article Text |
id | pubmed-4294390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-42943902015-01-21 Mastl kinase, a promising therapeutic target, promotes cancer recurrence Wang, Ling Luong, Vivian Q. Giannini, Peter J. Peng, Aimin Oncotarget Research Paper Mastl kinase promotes mitotic progression and cell cycle reentry after DNA damage. We report here that Mastl is frequently upregulated in various types of cancer. This upregulation was correlated with cancer progression in breast and oral cancer, poor patient survival in breast cancer, and tumor recurrence in head and neck squamous cell carcinoma. We further investigated the role of Mastl in tumor resistance using cell lines derived from the initial and recurrent tumors of the same head and neck squamous cell carcinoma patients. Ectopic expression of Mastl in the initial tumor cells strongly promoted cell proliferation in the presence of cisplatin by attenuating DNA damage signaling and cell death. Mastl knockdown in recurrent tumor cells re-sensitized their response to cancer therapy in vitro and in vivo. Finally, Mastl targeting specifically potentiated cancer cells to cell death in chemotherapy while sparing normal cells. Thus, this study revealed that Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy, and validated Mastl as a promising target to increase the therapeutic window. Impact Journals LLC 2014-12-22 /pmc/articles/PMC4294390/ /pubmed/25373736 Text en Copyright: © 2014 Wang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Research Paper Wang, Ling Luong, Vivian Q. Giannini, Peter J. Peng, Aimin Mastl kinase, a promising therapeutic target, promotes cancer recurrence |
title | Mastl kinase, a promising therapeutic target, promotes cancer recurrence |
title_full | Mastl kinase, a promising therapeutic target, promotes cancer recurrence |
title_fullStr | Mastl kinase, a promising therapeutic target, promotes cancer recurrence |
title_full_unstemmed | Mastl kinase, a promising therapeutic target, promotes cancer recurrence |
title_short | Mastl kinase, a promising therapeutic target, promotes cancer recurrence |
title_sort | mastl kinase, a promising therapeutic target, promotes cancer recurrence |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294390/ https://www.ncbi.nlm.nih.gov/pubmed/25373736 |
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