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Outcome of Adult Acute Lymphoblastic Leukemia in South East of Iran (Zahedan)

BACKGROUND: Acute lymphoblastic leukemia is a lymphoid malignancy, resulting from autonomous proliferation of monoclonal abnormal stem cell. The aim of this study was to evaluate the response rate and prognostic factor of adult patients suffering from acute lymphoblastic leukemia, who were treated w...

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Autores principales: Mashhadi, Mohammad Ali, Koushyar, Mohhamad Mahdi, Mohammadi, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Research Center, Shahid Beheshti University of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294535/
https://www.ncbi.nlm.nih.gov/pubmed/25628832
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author Mashhadi, Mohammad Ali
Koushyar, Mohhamad Mahdi
Mohammadi, Mehdi
author_facet Mashhadi, Mohammad Ali
Koushyar, Mohhamad Mahdi
Mohammadi, Mehdi
author_sort Mashhadi, Mohammad Ali
collection PubMed
description BACKGROUND: Acute lymphoblastic leukemia is a lymphoid malignancy, resulting from autonomous proliferation of monoclonal abnormal stem cell. The aim of this study was to evaluate the response rate and prognostic factor of adult patients suffering from acute lymphoblastic leukemia, who were treated with chemotherapy in south east of Iran and demographic methods were used for this study. METHODS: This study was conducted in Ali Ebne Abitaleb Hospital in south east of Iran (Zahedan) from 2003-2010. All adult patients with acute lymphoblastic leukemia in hematology ward received Vincristin, Daunorubicin, Cyclophosphamide, Prednisolone and high dose Methotrexate for induction therapy. All patients' information was recorded and multivariate analysis and survival studies were performed by using Kaplan-Meier statistics. RESULTS: Sixty six adult patients entered. Mean age of them was 33 years old (16-68), that 53 (80.3%) cases were male and 13 cases were female. Fifty one (77.3%) cases experienced complete remission and 15 (22.7%) cases had no remission state. In the following year 53% ( 33) was alive with complete remission and 47% ( 31) were dead. Median survival was 13 months. In the end of study 30 cases were in complete remission and alive and 36 (54.5%) were dead. CONCLUSION: Our results were comparable with other studies and minimally better than those studies.
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spelling pubmed-42945352015-01-27 Outcome of Adult Acute Lymphoblastic Leukemia in South East of Iran (Zahedan) Mashhadi, Mohammad Ali Koushyar, Mohhamad Mahdi Mohammadi, Mehdi Iran J Cancer Prev Original Article BACKGROUND: Acute lymphoblastic leukemia is a lymphoid malignancy, resulting from autonomous proliferation of monoclonal abnormal stem cell. The aim of this study was to evaluate the response rate and prognostic factor of adult patients suffering from acute lymphoblastic leukemia, who were treated with chemotherapy in south east of Iran and demographic methods were used for this study. METHODS: This study was conducted in Ali Ebne Abitaleb Hospital in south east of Iran (Zahedan) from 2003-2010. All adult patients with acute lymphoblastic leukemia in hematology ward received Vincristin, Daunorubicin, Cyclophosphamide, Prednisolone and high dose Methotrexate for induction therapy. All patients' information was recorded and multivariate analysis and survival studies were performed by using Kaplan-Meier statistics. RESULTS: Sixty six adult patients entered. Mean age of them was 33 years old (16-68), that 53 (80.3%) cases were male and 13 cases were female. Fifty one (77.3%) cases experienced complete remission and 15 (22.7%) cases had no remission state. In the following year 53% ( 33) was alive with complete remission and 47% ( 31) were dead. Median survival was 13 months. In the end of study 30 cases were in complete remission and alive and 36 (54.5%) were dead. CONCLUSION: Our results were comparable with other studies and minimally better than those studies. Cancer Research Center, Shahid Beheshti University of Medical Sciences 2012 /pmc/articles/PMC4294535/ /pubmed/25628832 Text en © 2014 Cancer Research Center, Shahid Beheshti University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Mashhadi, Mohammad Ali
Koushyar, Mohhamad Mahdi
Mohammadi, Mehdi
Outcome of Adult Acute Lymphoblastic Leukemia in South East of Iran (Zahedan)
title Outcome of Adult Acute Lymphoblastic Leukemia in South East of Iran (Zahedan)
title_full Outcome of Adult Acute Lymphoblastic Leukemia in South East of Iran (Zahedan)
title_fullStr Outcome of Adult Acute Lymphoblastic Leukemia in South East of Iran (Zahedan)
title_full_unstemmed Outcome of Adult Acute Lymphoblastic Leukemia in South East of Iran (Zahedan)
title_short Outcome of Adult Acute Lymphoblastic Leukemia in South East of Iran (Zahedan)
title_sort outcome of adult acute lymphoblastic leukemia in south east of iran (zahedan)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294535/
https://www.ncbi.nlm.nih.gov/pubmed/25628832
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