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Demographic and Prognostic Factors of 455 Patients with Acute Leukemia Admitted to Two Referral Hospitals in Tehran-Iran During Ten Years (2001-2011)

BACKGROUND: Global death toll of Acute Leukemia (AL), as a heterogeneous group of hematopoietic malignancies, is rather high, i.e. almost 74% of 300,000 new cases die every year. This reflects a poor prognosis of this malignancy in most parts of the world, where contemporary and rather complex remed...

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Autores principales: Ayremlou, Parvin, Razavi, Seyed Mohsen, Solaymani-Dodaran, Masoud, Vakili, Masoud, Asadi-Lari, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Research Center, Shahid Beheshti University of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294538/
https://www.ncbi.nlm.nih.gov/pubmed/25628835
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author Ayremlou, Parvin
Razavi, Seyed Mohsen
Solaymani-Dodaran, Masoud
Vakili, Masoud
Asadi-Lari, Mohsen
author_facet Ayremlou, Parvin
Razavi, Seyed Mohsen
Solaymani-Dodaran, Masoud
Vakili, Masoud
Asadi-Lari, Mohsen
author_sort Ayremlou, Parvin
collection PubMed
description BACKGROUND: Global death toll of Acute Leukemia (AL), as a heterogeneous group of hematopoietic malignancies, is rather high, i.e. almost 74% of 300,000 new cases die every year. This reflects a poor prognosis of this malignancy in most parts of the world, where contemporary and rather complex remedies are not available. There are a few well documented reports about the epidemiologic features of AL at national level in Iran. This retrospective study demonstrates demographic and laboratory features of Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) patients admitted to the main referral oncology hospitals in the ex-Iran University of Medical Sciences in Tehran (Firoozgar and Rasoul-Akram hospitals) during the last decade (2001-2011). METHODS: Medical records of all patients admitted to the both hospitals diagnosed with AML and ALL were reviewed during the study period for demographic, biological and clinical characteristics at diagnosis. RESULTS: Four-hundred fifty five patients were diagnosed with AML and ALL, who admitted to the both hospitals during ten years, of whom 59.6 % (271 patients) were male. Fifty five percent of patients had AML and 44.6 % had ALL, both significantly dominated in men (p<0.001). AML patients died more significantly (p<0.05) and the most deaths occurred in older patients (p<0.001). Initial WBC count was significantly related to death (p= 0.001), where the least death (13%) occurred in the group with initial WBC between 5-10×10(3)/μL and most of deceased had an initial WBC more than 10×10(3)/μL. Logistic regression showed that age, fever and WBC were significant prognostic factors. CONCLUSION: Demographic characteristics of AL patients were almost the same as other global reports. Most deaths occurred in older patients, those who had fever, and patients with higher WBC count at first admission, which warrants more investigations accurately and also improvements in hospital records.
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spelling pubmed-42945382015-01-27 Demographic and Prognostic Factors of 455 Patients with Acute Leukemia Admitted to Two Referral Hospitals in Tehran-Iran During Ten Years (2001-2011) Ayremlou, Parvin Razavi, Seyed Mohsen Solaymani-Dodaran, Masoud Vakili, Masoud Asadi-Lari, Mohsen Iran J Cancer Prev Case Series BACKGROUND: Global death toll of Acute Leukemia (AL), as a heterogeneous group of hematopoietic malignancies, is rather high, i.e. almost 74% of 300,000 new cases die every year. This reflects a poor prognosis of this malignancy in most parts of the world, where contemporary and rather complex remedies are not available. There are a few well documented reports about the epidemiologic features of AL at national level in Iran. This retrospective study demonstrates demographic and laboratory features of Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL) patients admitted to the main referral oncology hospitals in the ex-Iran University of Medical Sciences in Tehran (Firoozgar and Rasoul-Akram hospitals) during the last decade (2001-2011). METHODS: Medical records of all patients admitted to the both hospitals diagnosed with AML and ALL were reviewed during the study period for demographic, biological and clinical characteristics at diagnosis. RESULTS: Four-hundred fifty five patients were diagnosed with AML and ALL, who admitted to the both hospitals during ten years, of whom 59.6 % (271 patients) were male. Fifty five percent of patients had AML and 44.6 % had ALL, both significantly dominated in men (p<0.001). AML patients died more significantly (p<0.05) and the most deaths occurred in older patients (p<0.001). Initial WBC count was significantly related to death (p= 0.001), where the least death (13%) occurred in the group with initial WBC between 5-10×10(3)/μL and most of deceased had an initial WBC more than 10×10(3)/μL. Logistic regression showed that age, fever and WBC were significant prognostic factors. CONCLUSION: Demographic characteristics of AL patients were almost the same as other global reports. Most deaths occurred in older patients, those who had fever, and patients with higher WBC count at first admission, which warrants more investigations accurately and also improvements in hospital records. Cancer Research Center, Shahid Beheshti University of Medical Sciences 2012 /pmc/articles/PMC4294538/ /pubmed/25628835 Text en © 2014 Cancer Research Center, Shahid Beheshti University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Case Series
Ayremlou, Parvin
Razavi, Seyed Mohsen
Solaymani-Dodaran, Masoud
Vakili, Masoud
Asadi-Lari, Mohsen
Demographic and Prognostic Factors of 455 Patients with Acute Leukemia Admitted to Two Referral Hospitals in Tehran-Iran During Ten Years (2001-2011)
title Demographic and Prognostic Factors of 455 Patients with Acute Leukemia Admitted to Two Referral Hospitals in Tehran-Iran During Ten Years (2001-2011)
title_full Demographic and Prognostic Factors of 455 Patients with Acute Leukemia Admitted to Two Referral Hospitals in Tehran-Iran During Ten Years (2001-2011)
title_fullStr Demographic and Prognostic Factors of 455 Patients with Acute Leukemia Admitted to Two Referral Hospitals in Tehran-Iran During Ten Years (2001-2011)
title_full_unstemmed Demographic and Prognostic Factors of 455 Patients with Acute Leukemia Admitted to Two Referral Hospitals in Tehran-Iran During Ten Years (2001-2011)
title_short Demographic and Prognostic Factors of 455 Patients with Acute Leukemia Admitted to Two Referral Hospitals in Tehran-Iran During Ten Years (2001-2011)
title_sort demographic and prognostic factors of 455 patients with acute leukemia admitted to two referral hospitals in tehran-iran during ten years (2001-2011)
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294538/
https://www.ncbi.nlm.nih.gov/pubmed/25628835
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