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Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates

Endoplasmic reticulum α1,2 mannosidase I (ERManI), a central component of ER quality control and ER-associated degradation (ERAD), acts as a timer enzyme, modifying N-linked sugar chains of glycoproteins with time. This process halts glycoprotein folding attempts when necessary and targets terminall...

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Detalles Bibliográficos
Autores principales:	Benyair, Ron, Ogen-Shtern, Navit, Mazkereth, Niv, Shai, Ben, Ehrlich, Marcelo, Lederkremer, Gerardo Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294666/ https://www.ncbi.nlm.nih.gov/pubmed/25411339 http://dx.doi.org/10.1091/mbc.E14-06-1152

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