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Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review
Cannabinoids elicit complex hemodynamic responses in experimental animals that involve both peripheral and central sites. Centrally administered cannabinoids have been shown to predominantly cause pressor response. However, very little is known about the mechanism of the cannabinoid receptor 1 (CB(1...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294710/ https://www.ncbi.nlm.nih.gov/pubmed/25685481 http://dx.doi.org/10.1016/j.jare.2013.03.008 |
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author | Ibrahim, Badr M. Abdel-Rahman, Abdel A. |
author_facet | Ibrahim, Badr M. Abdel-Rahman, Abdel A. |
author_sort | Ibrahim, Badr M. |
collection | PubMed |
description | Cannabinoids elicit complex hemodynamic responses in experimental animals that involve both peripheral and central sites. Centrally administered cannabinoids have been shown to predominantly cause pressor response. However, very little is known about the mechanism of the cannabinoid receptor 1 (CB(1)R)-centrally evoked pressor response. In this review, we provided an overview of the contemporary knowledge regarding the cannabinoids centrally elicited cardiovascular responses and the possible underlying signaling mechanisms. The current review focuses on the rostral ventrolateral medulla (RVLM) as the primary brainstem nucleus implicated in CB(1)R-evoked pressor response. |
format | Online Article Text |
id | pubmed-4294710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-42947102015-02-14 Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review Ibrahim, Badr M. Abdel-Rahman, Abdel A. J Adv Res Review Cannabinoids elicit complex hemodynamic responses in experimental animals that involve both peripheral and central sites. Centrally administered cannabinoids have been shown to predominantly cause pressor response. However, very little is known about the mechanism of the cannabinoid receptor 1 (CB(1)R)-centrally evoked pressor response. In this review, we provided an overview of the contemporary knowledge regarding the cannabinoids centrally elicited cardiovascular responses and the possible underlying signaling mechanisms. The current review focuses on the rostral ventrolateral medulla (RVLM) as the primary brainstem nucleus implicated in CB(1)R-evoked pressor response. Elsevier 2014-03 2013-04-03 /pmc/articles/PMC4294710/ /pubmed/25685481 http://dx.doi.org/10.1016/j.jare.2013.03.008 Text en © 2013 Cairo University. Production and hosting by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Review Ibrahim, Badr M. Abdel-Rahman, Abdel A. Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review |
title | Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review |
title_full | Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review |
title_fullStr | Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review |
title_full_unstemmed | Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review |
title_short | Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review |
title_sort | cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294710/ https://www.ncbi.nlm.nih.gov/pubmed/25685481 http://dx.doi.org/10.1016/j.jare.2013.03.008 |
work_keys_str_mv | AT ibrahimbadrm cannabinoidreceptor1signalingincardiovascularregulatingnucleiinthebrainstemareview AT abdelrahmanabdela cannabinoidreceptor1signalingincardiovascularregulatingnucleiinthebrainstemareview |