Feasibility of optimizing trimetazidine dihydrochloride release from controlled porosity osmotic pump tablets of directly compressed cores

The aim of this study was to develop and optimize Trimetazidine dihydrochloride (TM) controlled porosity osmotic pump (CPOP) tablets of directly compressed cores. A 2(3) full factorial design was used to study the influence of three factors namely: PEG400 (10% and 25% based on coating polymer weight), coating level (10% and 20% of tablet core weight) and hole diameter (0 “no hole” and 1 mm). Other variables such as tablet cores, coating mixture of ethylcellulose (4%) and dibutylphthalate (2%) in 95% ethanol and pan coating conditions were kept constant. The responses studied (Y(i)) were cumulative percentage released after 2 h (Q%(2h)), 6 h (Q%(6h)), 12 h (Q%(12h)) and regression coefficient of release data fitted to zero order equation (RSQ(zero)), for Y(1), Y(2), Y(3), and Y(4), respectively. Polynomial equations were used to study the influence of different factors on each response individually. Response surface methodology and multiple response optimization were used to search for an optimized formula. Response variables for the optimized formula were restricted to 10% ⩽ Y(1) ⩽ 20%, 40% ⩽ Y(2) ⩽ 60%, 80% ⩽ Y(3) ⩽ 100%, and Y(4) > 0.9. The statistical analysis of the results revealed that PEG400 had positive effects on Q%2h, Q%6h and Q%12h, hole diameter had positive effects on all responses and coating level had positive effect on Q%(6h), Q%(12h) and negative effect on RSQ(zero). Full three factor interaction (3FI) equations were used for representation of all responses except Q%(2h) which was represented by reduced (3FI) equation. Upon exploring the experimental space, no formula in the tested range could satisfy the required constraints. Thus, direct compression of TM cores was not suitable for formation of CPOP tablets. Preliminary trials of CPOP tablets with wet granulated cores were promising with an intact membrane for 12 h and high RSQ(zero). Further improvement of these formulations to optimize TM release will be done in further studies.