1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review

This review article presents a survey of the utility of a new synthetic strategy for 1,3,4-thiadiazole derivatives based on reactions of nitrilimines with various functionalized sulfur dipolarophiles which proceed via tandem in situ 1,3-dipolar cycloaddition and β-elimination of simple molecule from...

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Detalles Bibliográficos
Autor principal: Shawali, Ahmad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294724/
https://www.ncbi.nlm.nih.gov/pubmed/25685467
http://dx.doi.org/10.1016/j.jare.2013.01.004
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author Shawali, Ahmad S.
author_facet Shawali, Ahmad S.
author_sort Shawali, Ahmad S.
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description This review article presents a survey of the utility of a new synthetic strategy for 1,3,4-thiadiazole derivatives based on reactions of nitrilimines with various functionalized sulfur dipolarophiles which proceed via tandem in situ 1,3-dipolar cycloaddition and β-elimination of simple molecule from the initially formed cycloadduct. The biological activities of some of the compounds prepared by such a strategy are pointed out. Only the literature reports within the period from 2000 to mid 2012 are covered.
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spelling pubmed-42947242015-02-14 1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review Shawali, Ahmad S. J Adv Res Review This review article presents a survey of the utility of a new synthetic strategy for 1,3,4-thiadiazole derivatives based on reactions of nitrilimines with various functionalized sulfur dipolarophiles which proceed via tandem in situ 1,3-dipolar cycloaddition and β-elimination of simple molecule from the initially formed cycloadduct. The biological activities of some of the compounds prepared by such a strategy are pointed out. Only the literature reports within the period from 2000 to mid 2012 are covered. Elsevier 2014-01 2013-04-06 /pmc/articles/PMC4294724/ /pubmed/25685467 http://dx.doi.org/10.1016/j.jare.2013.01.004 Text en © 2014 Cairo University. Production and hosting by Elsevier B.V. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Review
Shawali, Ahmad S.
1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review
title 1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review
title_full 1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review
title_fullStr 1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review
title_full_unstemmed 1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review
title_short 1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review
title_sort 1,3,4-thiadiazoles of pharmacological interest: recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294724/
https://www.ncbi.nlm.nih.gov/pubmed/25685467
http://dx.doi.org/10.1016/j.jare.2013.01.004
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